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Journal of Biochemical and Molecular Toxicology

Journal of Biochemical and Molecular Toxicology

IF: 3.2
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Study on the Effect of Naringenin on LPS-Induced Acute Lung Injury Based on NRF2/HO-1 Pathway

Published:4 June 2025 DOI: 10.1002/jbt.70333
Xiao-wei Wang, Da-gui Chen, Ci-an Zhang, Mu-yan Sun, Hao-hao Song, Chen-xi Zhang, Fu-sheng Shang, Min Ye

Abstract

Acute lung injury (ALI) is a serious respiratory disease characterized by pulmonary inflammatory cell infiltration and oxidative stress and is the leading cause of human death. Naringenin (NAR) is a naturally active flavonoid widely present in citrus fruits and has been shown to have multiple pharmacological effects. In this study, we evaluated the potential mechanism of NAR in lipopolysaccharide (LPS)-induced ALI by constructing a mice model of ALI. It was found that NAR significantly increased the 7-day survival rate of mice after LPS stimulation, improved lung index, tissue inflammatory infiltration, and fibrosis levels, and found that it decreased Interleukin-1 beta(IL-1β), Interleukin-6(IL-6), Tumor Necrosis Factor-alpha(TNF-α), and Malondialdehyde(MDA) levels in bronchoalveolar lavage fluid (BALF), while increasing Glutathione(GSH) and Superoxide Dismutase(SOD) levels. In addition, naringenin suppressed the expression of apoptotic proteins BCL2-Associated X Protein(BAX), Cysteine-Aspartate Protease 3(Caspase 3)and Cleaved-Caspase 3, promoted the expression of B-Cell Lymphoma 2(Bcl-2), and upregulated the expression of Nuclear Factor Erythroid 2-Related Factor 2(NRF2) and Heme Oxygenase-1(HO-1) in lung tissue. These studies suggest that naringenin ameliorates LPS-induced acute lung injury in mice by activating the NRF2/HO-1 pathway.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 566 suppliers $5.00-$10312.50
Naringenin 480-41-1 C15H12O5 - Inquiry
Naringenin 480-41-1 C15H12O5 - Inquiry

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