一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> British Journal of Pharmacology >>article
British Journal of Pharmacology

British Journal of Pharmacology

IF: 6.8
Download PDF

Salidroside attenuates the acquisition of morphine-induced conditioned place preference in mice via improving neurosynaptic plasticity in the ventral tegmental area

Published:9 June 2025 DOI: 10.1111/bph.70101 PMID: 40490964
Zhonghao Li, Xinru Mu, Qisheng Wang, Ziting Zhou, Zijing Wang, Yuxuan Wang, Qingyang Liu, Weixin Lin, Fenfen Qin, Haotian Pan, Jiamin Huang, Yun Gu, Qian Li, Yongwei Jiang, Shengfeng Lu, Qian Wang, Shanzhong Tan, Zhigang Lu

Abstract

Background and Purpose

Rhodiola rosea has therapeutic effects in several neurological disease models and its ethanolic extract prevents the acquisition of morphine-induced conditioned place preference (CPP). We investigate the potential mechanism by which the active component of R. rosea attenuates the acquisition of morphine-induced CPP and explore its association with synaptic plasticity.

Experimental Approach

Using systematic network pharmacology, morphine-treated SH-SY5Y cells and cortical primary neurons, we identified the active component of R. rosea against morphine addiction in vitro. Morphine-induced CPP and additional behavioural tests were conducted after salidroside treatment. Synaptic function and structural plasticity changes in the ventral tegmental area (VTA) were characterised via immunofluorescence staining, fibre photometry and western blot. RNA sequencing, qPCR and western blotting were used to elucidate the mechanism of salidroside in attenuating the acquisition of morphine-induced CPP.

Key Results

We identified salidroside as the key active component, which reduced intracellular Ca2+ levels in morphine-treated SH-SY5Y cells and reversed morphine-induced growth impairment in primary cortical neurons. Salidroside significantly inhibited the acquisition of morphine-induced CPP. Furthermore, salidroside reversed chronic morphine-induced alterations in synaptic function and structural plasticity in the VTA, as evidenced by both in vitro and in vivo data. Critically, salidroside enhanced neurosynaptic plasticity of dopaminergic neurons by upregulating PI3K-AKT signalling.

Conclusion and Implications

Our findings demonstrate that salidroside improves the synaptic structural and functional plasticity of VTA dopaminergic neurons through upregulating PI3K-AKT signalling, thereby attenuating the acquisition of morphine-induced CPP. Overall, salidroside exhibits promising preclinical potential as a therapeutic candidate for attenuating the acquisition of morphine-induced CPP.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Naloxone hydrochloride 357-08-4 C19H22ClNO4 288 suppliers $25.00-$1390.00
Naloxone hydrochloride 357-08-4 C19H22ClNO4 288 suppliers $25.00-$1390.00
Naloxone hydrochloride 357-08-4 C19H22ClNO4 288 suppliers $25.00-$1390.00
Naloxone hydrochloride 357-08-4 C19H22ClNO4 288 suppliers $25.00-$1390.00

Similar articles

IF:1.7

Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats

Asian Pacific journal of tropical biomedicine A. Alkaladi,?H. Ali,etc Published: 1 January 2020
IF:3.2

Syzygium Aromaticum Alleviates Cerium Chloride-Induced Neurotoxic Effect In The Adult Mice.

Toxicology Mechanisms and Methods Yamina Kadri, Riadh Nciri,etc Published: 1 January 2019
IF:3.8

Salidroside inhibits the growth of human breast cancer in vitro and in vivo.

Oncology reports Gang Zhao, Aiping Shi,etc Published: 1 May 2015
新邵县| 石屏县| 新田县| 仪陇县| 信阳市| 琼海市| 东莞市| 任丘市| 崇明县| 博乐市| 河津市| 南平市| 白银市| 怀仁县| 肃宁县| 滁州市| 射阳县| 竹溪县| 克什克腾旗| 通山县| 昭平县| 陆丰市| 涟源市| 遂宁市| 沭阳县| 思茅市| 托里县| 敦煌市| 绥阳县| 仙居县| 金坛市| 太和县| 海晏县| 四平市| 陵川县| 茂名市| 垣曲县| 汾阳市| 黎平县| 集安市| 稻城县|