一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> European journal of pharmacology >>article
European journal of pharmacology

European journal of pharmacology

IF: 4.2
Download PDF

Entospletinib alleviates acute liver injury and acute kidney injury by inhibiting ferroptosis

Published:10 July 2025 DOI: 10.1016/j.ejphar.2025.177939
Mingyuan Zhao , Yingying Lin , Qiang Zeng , Yan Li , Jianting Feng , Xuan Chen , Chuibing Lin , Libo Zhang , Yonghang Zhong , Junxiong Lin , Qiaofa Lin , Jingyi Li , Lanqin Wu , Xiaoru Liu , Lisheng Li

Abstract

Ferroptosis, an iron-dependent form of regulated cell death characterised by lipid peroxidation, has been implicated in the pathogenesis of various diseases and conditions, including organ injury, neurodegeneration, cancer, and autoimmune disorders. Inhibition of ferroptosis using small-molecule compounds is considered a promising approach for treating ferroptosis-related diseases. In this study, we screened a small-molecule compound library and identified entospletinib (Ent) as a universal and highly effective ferroptosis inhibitor. Ent inhibited ferroptosis induced by various stimuli and protected various cell lines from ferroptosis. Mechanistically, Ent reduced lipid peroxidation and suppressed the expression of haeme oxygenase 1 induced by RSL3. Furthermore, Ent alleviated concanavalin A-induced acute liver injury and cisplatin-induced acute kidney injury in vivo. Our findings demonstrate that Ent is an effective ferroptosis inhibitor, both in vivo and in vitro, suggesting its potential therapeutic value in the treatment of ferroptosis-related diseases.

Substances (48)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
Cisplatin 15663-27-1 Cl2H6N2Pt 921 suppliers $17.00-$7570.00
2,2-diphenyl-1-picrylhydrazyl 1898-66-4 C18H12N5O6* 348 suppliers $14.00-$1084.20
2,2-diphenyl-1-picrylhydrazyl 1898-66-4 C18H12N5O6* 348 suppliers $14.00-$1084.20
2,2-diphenyl-1-picrylhydrazyl 1898-66-4 C18H12N5O6* 348 suppliers $14.00-$1084.20
2,2-diphenyl-1-picrylhydrazyl 1898-66-4 C18H12N5O6* 348 suppliers $14.00-$1084.20
DEFEROXAMINE MESYLATE 138-14-7 C26H52N6O11S 291 suppliers $10.00-$2754.00
DEFEROXAMINE MESYLATE 138-14-7 C26H52N6O11S 291 suppliers $10.00-$2754.00

Similar articles

IF:5.3

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Lili Huang, Yuanyuan Wu,etc Published: 25 November 2024
IF:0

Evaluation of the Effect of Aminophylline in Reducing the Incidence of Acute Kidney Injury After Cardiac Surgery.

Anesthesiology and Pain Medicine Shahrbanoo Shahbazi, Peyman Alishahi,etc Published: 27 August 2017
IF:0.7

Alfacalcidol-Induced Kidney Injury in Patients with Severe Motor and Intellectual Disabilities.

Journal of nutritional science and vitaminology Osamu Uemura,?Yuka Hasegawa,etc Published: 1 January 2024
新巴尔虎右旗| 临沧市| 吴堡县| 利津县| 泸州市| 浦北县| 涡阳县| 治县。| 桂平市| 凤凰县| 大埔区| 芮城县| 兴文县| 霍山县| 吉安市| 永胜县| 南京市| 农安县| 普格县| 尚志市| 读书| 利川市| 丰原市| 万载县| 吉木乃县| 泸定县| 济源市| 昌宁县| 岐山县| 阿拉善左旗| 区。| 祁东县| 甘谷县| 金溪县| 汤阴县| 安化县| 乐业县| 宜良县| 江川县| 南岸区| 宜兰市|