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Scientific Reports

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An in vivo rat model for comparing selective blockade between sensory and motor nerve conduction

Published:20 July 2025 DOI: 10.1038/s41598-025-12201-5 PMID: 40685446
Yi Teng,?Xian Zou,?Jin Liu,?Xiangyu Hu,?Cheng Zhou,?Mengchan Ou

Abstract

Sensory-selective nerve blockade is highly useful for pain management in clinical practice, but developing such blockers remains challenging. A major handicap is the lack of objective in vivo animal models to evaluate motor and sensory nerve conduction simultaneously. Due to anatomical structures, motor evoked potentials (MEPs) and/or somatosensory evoked potentials (SSEPs) may be used to assess nerve conduction. MEPs were elicited by stimulating motor cortex and recorded from contralateral hind limb. SSEPs were generated by stimulating sciatic nerve and recorded from contralateral sensory cortex. Amplitude/latency changes were recorded under various physiological conditions (e.g., anesthesia, durations, temperatures, and oxygen) and drug interventions for validation. Compared to sevoflurane, propofol minimally inhibited MEPs at sedative doses and was therefore used during recordings. Both hypothermia (34-36 °C) and hyperthermia (38-40 °C) significantly suppressed MEP and SSEP amplitudes (P?2) decreased MEP amplitudes (P?2 (R2?=?0.8284). For selective blockade validation, lidocaine suppressed both MEP and SSEP amplitudes below 20% of baseline (P?

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Capsaicin 404-86-4 C18H27NO3 858 suppliers $28.00-$2485.00
Capsaicin 404-86-4 C18H27NO3 858 suppliers $28.00-$2485.00
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