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International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.6
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Sulforaphane-Rich Broccoli Sprout Extract Promotes Hair Regrowth in an Androgenetic Alopecia Mouse Model via Enhanced Dihydrotestosterone Metabolism

Published:1 August 2025 DOI: 10.3390/ijms26157467 PMID: 40806594
Laxman Subedi,?Duc Dat Le,?Eunbin Kim,?Susmita Phuyal,?Arjun Dhwoj Bamjan,?Vinhquang Truong,?Nam Ah Kim,?Jung-Hyun Shim,?Jong Bae Seo,?Suk-Jung Oh,?Mina Lee,?Jin Woo Park

Abstract

Androgenetic alopecia (AGA) is a common progressive hair loss disorder driven by elevated dihydrotestosterone (DHT) levels, leading to follicular miniaturization. This study investigated sulforaphane-rich broccoli sprout extract (BSE) as a potential oral therapy for AGA. BSE exhibited dose-dependent proliferative and migratory effects on keratinocytes, dermal fibroblasts, and dermal papilla cells, showing greater in vitro activity than sulforaphane (SFN) and minoxidil under the tested conditions, while maintaining low cytotoxicity. In a testosterone-induced AGA mouse model, oral BSE significantly accelerated hair regrowth, with 20 mg/kg achieving 99% recovery by day 15, alongside increased follicle length, density, and hair weight. Mechanistically, BSE upregulated hepatic and dermal DHT-metabolizing enzymes (Akr1c21, Dhrs9) and activated Wnt/β-catenin signaling in the skin, suggesting dual actions via androgen metabolism modulation and follicular regeneration. Pharmacokinetic analysis revealed prolonged SFN plasma exposure following BSE administration, and in silico docking showed strong binding affinities of key BSE constituents to Akr1c2 and β-catenin. No systemic toxicity was observed in liver histology. These findings indicate that BSE may serve as a safe, effective, and multitargeted natural therapy for AGA. Further clinical studies are needed to validate its efficacy in human populations.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
DL-Sulforaphane 4478-93-7 C6H11NOS2 422 suppliers $16.00-$2425.50
DL-Sulforaphane 4478-93-7 C6H11NOS2 422 suppliers $16.00-$2425.50
DL-Sulforaphane 4478-93-7 C6H11NOS2 422 suppliers $16.00-$2425.50
DL-Sulforaphane 4478-93-7 C6H11NOS2 422 suppliers $16.00-$2425.50
Sulforaphane 4478-93-7 - Inquiry
Sulforaphane 4478-93-7 - Inquiry

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