一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Molecular Sciences >>article
International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.6
Download PDF

Design, Synthesis, and Biological Activity Studies of Aldisine Derivatives Containing Acylhydrazone Moiety

Published:27 August 2025 DOI: 10.3390/ijms26178308 PMID: 40943231
Wentao Xu,?Kangkang Yang,?Mingxing Li,?Longqi Li,?Fuqiao Xing,?Jiayi Li,?Yuxiu Liu,?Jingjing Zhang,?Qingmin Wang,?Hongjian Song

Abstract

Marine natural products have gained increasing interest in drug research and development because of their unique structures, diverse biological activities, and novel mechanisms of action. Using the antiviral alkaloid aldisine as the lead compound and utilizing the hydrogen bond effects common in drug design, novel derivatives containing an acylhydrazone moiety were designed and synthesized. The structures of these derivatives were systematically analyzed using variable-temperature 1H-NMR. Antiviral activity tests showed that most derivatives were active against tobacco mosaic virus (TMV), with some compounds outperforming the commercial antiviral drug ribavirin. Notably, 3-methylphenyl- and 3-pyridyl-substituted acylhydrazones 5-6 and 5-12 displayed activity comparable to ningnanmycin, one of the most effective commercial antiviral agents. Molecular docking results indicated that incorporating the acylhydrazone moiety enhances hydrogen bonding between the molecules and target proteins. Additionally, we evaluated the fungicidal and larvicidal activities of these derivatives. Most exhibited significant larvicidal effects against Mythimna separata and Plutella xylostella, along with broad-spectrum fungicidal activity. Four related compounds (5-11, 5-12, 5-13, and 5-17) exhibited high fungicidal activities, and another four compounds (2-4, 5-6, 5-13, and 5-17) exhibited high larvicidal activities.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00

Similar articles

IF:3.2

Capsaicin derivatives: Synthesis and biological activity

Chemical Biology & Drug Design Shun Liu, Xing Zheng,etc Published: 5 February 2024
IF:6

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives

European Journal of Medicinal Chemistry Zahra Rezaei , Soghra Khabnadideh ,etc Published: 1 July 2009
IF:1.8

Synthesis of 2-Aminobenzophenone Derivatives and Their Anticancer Activity

Synthetic Communications Sandra Cortez-Maya,?E. Cortés,etc Published: 1 January 2012
肇州县| 西乌| 格尔木市| 漳平市| 禄丰县| 涿鹿县| 托里县| 若羌县| 观塘区| 玉山县| 康保县| 泾阳县| 永丰县| 陵川县| 丹寨县| 舒城县| 元朗区| 禹州市| 专栏| 思茅市| 徐汇区| 吴桥县| 婺源县| 汤原县| 同心县| 响水县| 高安市| 紫金县| 香河县| 温州市| 永康市| 舟山市| 辰溪县| 汉川市| 洪江市| 安阳县| 上虞市| 宁晋县| 永济市| 科技| 南投县|