一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Molecular Sciences >>article
International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.6
Download PDF

Design, Synthesis, and Biological Activity Studies of Aldisine Derivatives Containing Acylhydrazone Moiety

Published:27 August 2025 DOI: 10.3390/ijms26178308 PMID: 40943231
Wentao Xu,?Kangkang Yang,?Mingxing Li,?Longqi Li,?Fuqiao Xing,?Jiayi Li,?Yuxiu Liu,?Jingjing Zhang,?Qingmin Wang,?Hongjian Song

Abstract

Marine natural products have gained increasing interest in drug research and development because of their unique structures, diverse biological activities, and novel mechanisms of action. Using the antiviral alkaloid aldisine as the lead compound and utilizing the hydrogen bond effects common in drug design, novel derivatives containing an acylhydrazone moiety were designed and synthesized. The structures of these derivatives were systematically analyzed using variable-temperature 1H-NMR. Antiviral activity tests showed that most derivatives were active against tobacco mosaic virus (TMV), with some compounds outperforming the commercial antiviral drug ribavirin. Notably, 3-methylphenyl- and 3-pyridyl-substituted acylhydrazones 5-6 and 5-12 displayed activity comparable to ningnanmycin, one of the most effective commercial antiviral agents. Molecular docking results indicated that incorporating the acylhydrazone moiety enhances hydrogen bonding between the molecules and target proteins. Additionally, we evaluated the fungicidal and larvicidal activities of these derivatives. Most exhibited significant larvicidal effects against Mythimna separata and Plutella xylostella, along with broad-spectrum fungicidal activity. Four related compounds (5-11, 5-12, 5-13, and 5-17) exhibited high fungicidal activities, and another four compounds (2-4, 5-6, 5-13, and 5-17) exhibited high larvicidal activities.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00
Ribavirin 36791-04-5 C8H12N4O5 744 suppliers $5.00-$3050.00

Similar articles

IF:3.2

Capsaicin derivatives: Synthesis and biological activity

Chemical Biology & Drug Design Shun Liu, Xing Zheng,etc Published: 5 February 2024
IF:6

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives

European Journal of Medicinal Chemistry Zahra Rezaei , Soghra Khabnadideh ,etc Published: 1 July 2009
IF:1.8

Synthesis of 2-Aminobenzophenone Derivatives and Their Anticancer Activity

Synthetic Communications Sandra Cortez-Maya,?E. Cortés,etc Published: 1 January 2012
澄江县| 昌乐县| 成安县| 威远县| 柳河县| 永泰县| 开封市| 东至县| 嵊州市| 博野县| 阿克苏市| 鄄城县| 昌图县| 区。| 革吉县| 临桂县| 祁门县| 阜康市| 林州市| 余干县| 乌审旗| 英山县| 巩留县| 宜黄县| 丹凤县| 江阴市| 南岸区| 周至县| 桐庐县| 连平县| 布拖县| 福贡县| 景宁| 峡江县| 慈利县| 九寨沟县| 辛集市| 榆树市| 蓝山县| 获嘉县| 屏南县|