一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Frontiers in Pharmacology >>article
Frontiers in Pharmacology

Frontiers in Pharmacology

IF: 4.4
Download PDF

Tetramethylpyrazine exerts neuroprotective effects in a mouse model of acute hypobaric hypoxia

Published:15 October 2025 DOI: 10.3389/fphar.2025.1662389 PMID: 41170376
Xiong Lan,?Wei Zhou,?Lei Zhou,?Huifang Deng,?Pan Shen,?Zhijie Bai,?Chaoji Huangfu,?Ningning Wang,?Yue Sun,?Chengrong Xiao,?Zengchun Ma,?Pengfei Zhang,?Yue Gao

Abstract

Introduction: Cognitive impairment is a common issue for individuals ascending to high-altitude regions, and there is currently a lack of effective preventive or therapeutic medications. Tetramethylpyrazine (TMP), a small-molecule compound with blood-brain barrier permeability, has shown neuroprotective effects in various neurological disorders. This study aimed to investigate its potential protective role against hypoxia-induced cognitive deficits.

Methods: The neuroprotective effects of TMP were evaluated both in vivo and in vitro. A simulated high-altitude hypobaric hypoxia mouse model was used to assess survival, cognitive function, cerebral ATP levels, and hippocampal histopathology. In vitro studies were conducted to examine hypoxia-induced neuronal death using primary neurons and HT22 cells. Furthermore, mechanistic investigations were performed to identify the molecular target of TMP and its functional impact.

Results: TMP treatment significantly prolonged survival and alleviated cognitive impairment in mice exposed to hypobaric hypoxia. It also elevated cerebral ATP levels and reduced hippocampal cellular edema. In vitro, TMP reduced hypoxia-induced neuronal death. Mechanistically, TMP was identified to potentially bind to the ion channel protein KCNK2 (TREK-1) and inhibit TREK-1-mediated current.

Discussion: Our findings demonstrate that TMP provides significant neuroprotection under hypobaric hypoxia conditions. The mechanism is linked, at least in part, to the inhibition of the TREK-1 channel. These results position TMP as a promising therapeutic candidate for preventing or treating high-altitude-induced cognitive dysfunction.

Similar articles

IF:6.2

Neuroprotective effects of Ginkgo biloba extract.

Cellular and Molecular Life Sciences B Ahlemeyer,?J Krieglstein,etc Published: 1 September 2003
IF:2.9

Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature.

Current topics in medicinal chemistry Seyed Mohammad Nabavi, Solomon Habtemariam,etc Published: 1 January 2015
IF:4.6

In Vitro and In Vivo Neuroprotective Effects of Sarcosine.

ACS Applied Bio Materials Arzugül Tanas, ?zlem ?zdemir Tozlu,etc Published: 15 October 2022
房产| 理塘县| 娄底市| 石城县| 全州县| 望奎县| 民和| 新野县| 安阳市| 会泽县| 临江市| 磐石市| 龙江县| 顺昌县| 皋兰县| 定远县| 中方县| 满洲里市| 滨州市| 益阳市| 商城县| 天气| 神农架林区| 会昌县| 遵义县| 北海市| 武穴市| 永安市| 勃利县| 崇文区| 咸阳市| 兴安县| 格尔木市| 长武县| 普兰店市| 安龙县| 綦江县| 浙江省| 巍山| 博白县| 丘北县|