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Marine Drugs

Marine Drugs

IF: 4.9
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Identifying a Marine-Derived Small-Molecule Nucleoprotein Inhibitor Against Influenza A Virus

Published:23 October 2025 DOI: 10.3390/md23110413 PMID: 41295381
Zihan Wang,?Yang Zhang,?Shangjie Xu,?Lishan Sun,?Hongwei Zhao,?Wei Wang

Abstract

Influenza A virus (IAV) poses a major threat to global public health, exerting immense pressure on human health and the economy. The IAV nucleoprotein (NP) is an ideal target for antiviral drug development. Through Mini-genome and Surface Plasmon Resonance assays, this study discovered and verified that mycophenolic acid methyl ester (MAE), a secondary metabolite produced by the marine algal-associated fungus Phaeosphaeria spartinae, can target the viral nucleoprotein to exert anti-IAV activity. Pull-down assays and immunofluorescence have revealed that MAE blocks the nuclear import of viral ribonucleoprotein complexes (vRNP) by interfering with the interaction between NP and IMP-α. It also affects the vRNP assembly process by regulating NP oligomerization and the interaction between NP and PB2. In addition, Sandwich ELISA and Electron Microscopy experiments showed that MAE can also inactivate viral particles to reduce the risk of infection. Comprehensive research results indicate that MAE exerts its effects by inhibiting the viral NP protein, which has laid an important foundation for the development of marine-derived NP-targeted drugs.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Methyl Mycophenolate (EP Impurity E) 31858-66-9 C18H22O6 92 suppliers $44.00-$2000.00
Methyl Mycophenolate (EP Impurity E) 31858-66-9 C18H22O6 92 suppliers $44.00-$2000.00
Methyl Mycophenolate (EP Impurity E) 31858-66-9 C18H22O6 92 suppliers $44.00-$2000.00
Methyl Mycophenolate (EP Impurity E) 31858-66-9 C18H22O6 92 suppliers $44.00-$2000.00

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