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Journal of Hazardous Materials

Journal of Hazardous Materials

IF: 12.2
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ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes

Published:15 May 2021 DOI: 10.1016/j.jhazmat.2020.124566 PMID: 33323305
Xuan Lai , Menglei Wang , Yixia Zhu , Xiaoli Feng , Huimin Liang , Junrong Wu , Li Nie , Li Li , Longquan Shao

Abstract

Background

This study aimed to evaluate the safety of applying zinc oxide nanoparticles (ZnO NPs) to pathological skin. The majority of previous studies confirmed the safety of applying ZnO NPs to normal skin. However, we know very little about the risks of using sunscreen, cosmetics and topical drugs containing ZnO NPs for individuals with skin diseases.

Results

ZnO NPs passed through gaps between keratinocytes and entered stratum basale of epidermis and dermis in imiquimod-induced psoriasis-like skin lesions. Application of a ZnO NP-containing suspension for 3 connective days delayed the healing of the epidermal barrier; increased the expression levels of inflammatory cytokines; promoted keratinocyte apoptosis and disturbed redox homeostasis. In TNF-α-stimulated HaCaT cells, QNZ and JSH-23 (NFκB inhibitors) blocked ZnO NP-induced inflammation. JSH-23 and NAC (a precursor of cysteine) inhibited ZnO NP-induced nuclear translocation of p-NFκB p65, cysteine deficiency and apoptosis. Additionally, ZnO NPs decreased CD98 level in main pathway and failed to activate transsulfuration pathway in cysteine biosynthesis.

Conclusions

ZnO NPs can enter psoriasis-like skin lesions and promote inflammation and keratinocyte apoptosis through nuclear translocation of p-NFκB p65 and cysteine deficiency. This work reminds the public that ZnO NPs have harmful effects on the recovery of inflammatory skin diseases.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1 C16H20N2 155 suppliers $12.00-$1600.00
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1 C16H20N2 155 suppliers $12.00-$1600.00
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1 C16H20N2 155 suppliers $12.00-$1600.00
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1 C16H20N2 155 suppliers $12.00-$1600.00
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE 545380-34-5 C22H20N4O 153 suppliers $20.00-$2023.00
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE 545380-34-5 C22H20N4O 153 suppliers $20.00-$2023.00
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE 545380-34-5 C22H20N4O 153 suppliers $20.00-$2023.00
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE 545380-34-5 C22H20N4O 153 suppliers $20.00-$2023.00

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