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Carbohydrate Polymers

Carbohydrate Polymers

IF: 10.7
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Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells.

Published:1 January 2021 DOI: 10.1016/j.carbpol.2020.117088 PMID: 33142629
Shuxin Jiang , Huanan Yin , Xiaohui Qi , Weiguo Song , Weiwei Shi , Jiaojiao Mou , Jie Yang

Abstract

Sea cucumbers were nutritional food and traditional Chinese medicine. In this study, fucosylated chondroitin sulfate from sea cucumber Stichopus chloronotus (fCS-Sc), a potential anticoagulant agent and immunological adjuvant, was investigated for its immune activation effects on RAW 264.7 macrophage for the first time. The results indicated that fCS-Sc could significantly promote the proliferation, the pinocytic activity of RAW 264.7 cells, and the production of NO, TNF-α, IL-1β, and IL-6. The fluorescence labeling assay indicated that fCS-Sc could bind to the macrophage. Moreover, the specific pattern recognition receptor inhibition assays showed that toll-like receptor 4 (TLR4) and TLR2 were involved in the recognition of fCS-Sc. Western blot assays indicated that fCS-Sc could induce degradation of cytoplasm IκB-α, and promotion of NF-κB p65 subunit translocation to nucleus, leading to a functional improvement of macrophage through NF-κB pathway. The results suggested that fCS-Sc might served as a promising candidate of immunomodulator.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00
TLR2-IN-C29 363600-92-4 C16H15NO4 99 suppliers $13.00-$2500.00

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