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European journal of pharmacology

European journal of pharmacology

IF: 4.2
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Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells

Published:14 June 2007 DOI: 10.1016/j.ejphar.2007.01.089 PMID: 17349619
Li Zhang , Huixin Yu , Yang Sun , Xiufeng Lin , Bo Chen , Chen Tan , Guoxian Cao , Zhengwu Wang

Abstract

Oxidative stress plays an important role in Alzheimer's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L, shows potent antioxidant property. In this paper, the neuroprotective effects of salidroside on hydrogen peroxide (H2O2)-induced apoptosis in SH-SY5Y cells were investigated. Pretreatment with salidroside markedly attenuated H2O2-induced cell viability loss and apoptotic cell death in a dose-dependent manner. The mechanisms by which salidroside protected neuron cells from oxidative stress included the induction of several antioxidant enzymes, thioredoxin, heme oxygenase-1, and peroxiredoxin-I; the downregulation of pro-apoptotic gene Bax and the upregulation of anti-apoptotic genes Bcl-2 and Bcl-XL. Furthermore, salidroside dose-dependently restored H2O2-induced loss of mitochondrial membrane potential as well as the elevation of intracellular calcium level. These results suggest that salidroside has protective effects against oxidative stress-induced cell apoptosis, which might be a potential therapeutic agent for treating or preventing neurodegenerative diseases implicated with oxidative stress.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Diphenhydramine Hydrochloride 147-24-0 C17H22ClNO 782 suppliers $5.00-$1593.90
Salidroside 10338-51-9 C14H20O7 681 suppliers $5.00-$2053.00
Bcl-2 71 suppliers Inquiry
HEAT SHOCK PROTEIN 32 1355645-85-0 53 suppliers Inquiry
THIOREDOXIN 52500-60-4 39 suppliers $88.00-$644.00
Bcl-XL 28 suppliers Inquiry
Peroxiredoxin I 1 suppliers Inquiry

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