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ChemicalBook >> journal list >> Proceedings of the National Academy of Sciences of the United States of America >>article

Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U: the phenylacetyl-CoA catabolon.

Published:26 May 1998 DOI: 10.1073/pnas.95.11.6419 PMID: 9600981
E R Olivera, B Mi?ambres, B García, C Mu?iz, M A Moreno, A Ferrández, E Díaz, J L García, J M Luengo

Abstract

Fourteen different genes included in a DNA fragment of 18 kb are involved in the aerobic degradation of phenylacetic acid by Pseudomonas putida U. This catabolic pathway appears to be organized in three contiguous operons that contain the following functional units: (i) a transport system, (ii) a phenylacetic acid activating enzyme, (iii) a ring-hydroxylation complex, (iv) a ring-opening protein, (v) a beta-oxidation-like system, and (vi) two regulatory genes. This pathway constitutes the common part (core) of a complex functional unit (catabolon) integrated by several routes that catalyze the transformation of structurally related molecules into a common intermediate (phenylacetyl-CoA).

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Procduct Name CAS Molecular Formula Supplier Price
Phenylacetyl-CoA 7532-39-0 C29H42N7O17P3S 16 suppliers $154.00-$2100.00

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