一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Materials & Design >>article
Materials & Design

Materials & Design

IF: 7.9
Download PDF

Cell adhesion inhibiting peptides exhibit potent anticancer activity and modulate intestinal microbiota

Published:1 December 2022 DOI: 10.1016/j.matdes.2022.111303
Yu-Fon Chen , Yao-Tsung Yeh , Yu-Chu Su , Chorng-An Liao , Cheng-Hsieh Huang , Ying-Jung Cheng , Jeng-Shiung Jan

Abstract

Membrane E-cadherin is one of the proteins whose expression affects cancer cell migration and adhesion. The design of peptide drugs that target such cancer cell-specific characteristics have received great attention in recent years and cysteine derivatives in particular have been shown to enhance anticancer effects. Herein, we set out to investigate the anticancer activity of a cell adhesion inhibiting peptide comprised of l-lysine (Lys) and Benzyl-l-cysteine (BnCys) and its influence on intestinal microbiota. The peptide inhibits cell migration and adhesion by interfering E-cadherin packaging, perturbing the integrity of cell membrane, and triggering caspase-3 and PARP related apoptotic pathways. It is highly possible that the cationic Lys segment would bind with the negatively charged cadherin molecules and the bulky BnCys segment would act as a spacing moiety to prevent the packing of E-cadherin. The peptide mixed with low-dose cisplatin effectively inhibits tumor growth and metastasis without incurring weight loss, prolonging the survival of tumor-bearing mice. The peptide treatment group increases the relative proportion of intestinal Akkermansia muciniphila (Akk), suggesting at prebiotic properties. These results paint a promising picture for designing cell migration/adhesion inhibiting peptides to target membrane E-cadherin for anticancer therapy.

江安县| 华阴市| 基隆市| 中超| 邢台市| 湟中县| 芷江| 冀州市| 石台县| 龙海市| 阿勒泰市| 伊金霍洛旗| 白玉县| 阳曲县| 栾城县| 洪洞县| 金平| 永新县| 黄陵县| 乡宁县| 秭归县| 上林县| 正镶白旗| 呼伦贝尔市| 邯郸市| 大丰市| 淮滨县| 疏勒县| 历史| 新疆| 中西区| 阜平县| 大港区| 凌源市| 库伦旗| 朔州市| 昭苏县| 囊谦县| 浦北县| 临清市| 静乐县|