一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Experimental cell research >>article
Experimental cell research

Experimental cell research

IF: 3.3
Download PDF

Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression

Published:1 May 2021 DOI: 10.1016/j.yexcr.2021.112526 PMID: 33631165
Zihan Zheng , Bo Wang , Xiaohan Lv , Feng Yao , Hongqian Gao , Zhen Jin , Yizhen Liu , Ying Deng , Danli Chen , Xuan Ning , Weirong Wang , Jianyu He , Rong Lin

Abstract

Sirtuins are a family of highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent enzymes. Among the sirtuins, SIRT1 and SIRT6 participate in the regulation of endothelial functions and play significant roles in the physiological and pathological processes of cardiovascular diseases (CVD). Recently, our study found that minute cholesterol crystals (CC) can be endocytosed by endothelial cells and further impair endothelial functions. Since previous studies have reported that angiotensin-converting enzyme (ACE2) involves Angiotensin (Ang) II-induced inflammation in endothelial cells, this study was designed to investigate the role of SIRT1 and SIRT6 in CC-induced variation of ACE2 expression and the related mechanism between SIRT6 and ACE2. We found that ACE2 is involved in CC-induced endothelial dysfunction, which inhibits decreases in nitric oxide (NO) level and endothelial nitric oxide synthase (eNOS) activity and increases in inflammatory factors and adhesion molecules. Besides, SIRT1 and SIRT6 regulated the protein expression of ACE2 in CC-stimulated human umbilical vein endothelial cells (HUVECs). Moreover, bioinformatics analysis from the Enrichr database indicated that activating transcription factor 2 (ATF2), is highly correlated with genes that significantly upregulated after infection with the SIRT6 adenovirus vector. In CC-induced HUVECs, ACE2 expression was up-regulated in cells transfected with ATF2 siRNA. However, further mechanism studies revealed that overexpression of SIRT6 decreases the accumulation of p-ATF2 in the nucleus, but did not affect p-ATF2 expression in the cytoplasm. Taken together, these data indicated that SIRT6 regulates ACE2 might via inhibiting the accumulation of nucleus p-ATF2 in CC-induced endothelial dysfunction.

Similar articles

IF:4.2

Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells

European journal of pharmacology Li Zhang , Huixin Yu ,etc Published: 14 June 2007
IF:0

Protective effect of sulforaphane against oxidative stress: Recent advances

Experimental and Toxicologic Pathology Carlos Enrique Guerrero-Beltrán , Mariel Calderón-Oliver ,etc Published: 1 July 2012
蚌埠市| 托克逊县| 乳山市| 大埔县| 霍城县| 射阳县| 阳新县| 临邑县| 汉寿县| 洛川县| 平安县| 岗巴县| 师宗县| 古蔺县| 广德县| 浮山县| 南郑县| 县级市| 玉溪市| 峡江县| 栾川县| 含山县| 长治市| 汝城县| 灯塔市| 大邑县| 都昌县| 景洪市| 舒城县| 德阳市| 布尔津县| 黔西县| 新绛县| 南川市| 门头沟区| 临澧县| 黄陵县| 乌拉特中旗| 祁门县| 郧西县| 平乐县|