一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell reports >>article
Cell reports

Cell reports

IF: 7.5
Download PDF

Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.

Published:23 March 2021 DOI: 10.1016/j.celrep.2021.108901 PMID: 33761347
Mingfu Liang, Gaowei Jin, Xingqiao Xie, Wenchao Zhang, Kaiyue Li, Fengfeng Niu, Cong Yu, Zhiyi Wei

Abstract

Synaptic scaffold proteins (e.g., liprin-α, ELKS, RIM, and RIM-BP) orchestrate ion channels, receptors, and enzymes at presynaptic terminals to form active zones for neurotransmitter release. The underlying mechanism of the active zone assembly remains elusive. Here, we report that liprin-α proteins have the potential to oligomerize through the N-terminal coiled-coil region. Our structural and biochemical characterizations reveal that a gain-of-function mutation promotes the self-assembly of the coiled coils in liprin-α2 by disrupting intramolecular interactions and promoting intermolecular interactions. By enabling multivalent interactions with ELKS proteins, the oligomerized coiled-coil region of liprin-α2 enhances the phase separation of the ELKS N-terminal segment. We further show that liprin-α2, by regulating the interplay between two phase separations of ELKS and RIM/RIM-BP, controls the protein distributions. These results imply that the complicated protein-protein interactions allow liprin-α to function with the active zone scaffolds and compartmentalize protein assemblies to achieve comprehensive functions in the active zone.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
1,6-Hexanediol 629-11-8 C6H14O2 597 suppliers $6.00-$2600.00

Similar articles

IF:3

DSN1 Interaction With Centromere‐Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma

Molecular Carcinogenesis Hongrui Zhou, Mengxue Zhang,etc Published: 19 November 2024
IF:2.9

Dess–Martin periodinane oxidative rearrangement for preparation of α-keto thioesters1

Organic & Biomolecular Chemistry Randy Sanichar , Ciaran Carroll ,etc Published: 1 January 2018
如东县| 大石桥市| 新和县| 曲靖市| 西丰县| 大邑县| 牡丹江市| 噶尔县| 布尔津县| 平阴县| 太康县| 方城县| 北安市| 香格里拉县| 百色市| 青州市| 白银市| 湘潭市| 海宁市| 大关县| 酒泉市| 五寨县| 马鞍山市| 蓝山县| 琼结县| 通州市| 聊城市| 象州县| 巴塘县| 东丽区| 松原市| 利辛县| 凉山| 仁布县| 章丘市| 南涧| 富锦市| 安多县| 根河市| 农安县| 绩溪县|