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Mediators of Inflammation

Mediators of Inflammation

IF: 4.4
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Mechanism of action of 5-arninosalicylic acid.

Published:1 January 1992 DOI: 10.1155/S0962935192000243 PMID: 18475455
N A Punchard, S M Greenfield, R P Thompson

Abstract

5-Aminosalicylic Acid (5-ASA) has been used for over 50 years in the treatment of inflammatory bowel disease in the pro-drug form sulphasalazine (SASP). SASP is also used to treat rheumatoid arthritis. However whether the therapeutic properties of SASP are due to the intact molecule, the 5-ASA or sulphapyridine components is unknown. Several mechanisms of action have been proposed for 5-ASA and SASP including interference in the metabolism of arachidonic acid to prostaglandins and leukotrienes, scavenging,of reactive oxygen species, effects on leucocyte function and production of cytokines. However, it is unlikely that the anti-inflammatory properties of SASP and 5-ASA are due to several different properties but more likely that a single property of 5-ASA explains the theraapeutic effects of 5-ASA and SASP. Reactive oxygen species (ROS) are involved in the metabolism of prostaglandins and leukotrienes and can act as second messengers, and so the scavenging of ROS may be the single mechanism of action of 5-ASA that gives rise to its antiinflammatory effects in both inflammatory bowel disease and rheumatoid arthritis.

Substances (5)

Related products
Procduct Name CAS Molecular Formula Supplier Price
5-Aminosalicylic acid 89-57-6 C7H7NO3 957 suppliers $5.00-$1880.00
Sulfasalazine 599-79-1 C18H14N4O5S 475 suppliers $7.00-$690.00
Sulfapyridine 144-83-2 C11H11N3O2S 427 suppliers $5.00-$1880.00
ROS 37 suppliers Inquiry
Reactive Oxygen Species 1 suppliers Inquiry

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