一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Vascular Health and Risk Management >>article

Vascular Health and Risk Management

IF: 2.6
Download PDF

Ezetimibe therapy: mechanism of action and clinical update.

Published:1 January 2012 DOI: 10.2147/VHRM.S33664 PMID: 22910633
Binh An P Phan,?Thomas D Dayspring,?Peter P Toth

Abstract

The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events. Although statin therapy is the mainstay for LDL-C lowering, a significant percentage of patients prescribed these agents either do not achieve targets with statin therapy alone or have partial or complete intolerance to them. For such patients, the use of adjuvant therapy capable of providing incremental LDL-C reduction is advised. One such agent is ezetimibe, a cholesterol absorption inhibitor that targets uptake at the jejunal enterocyte brush border. Its primary target of action is the cholesterol transport protein Nieman Pick C1 like 1 protein. Ezetimibe is an effective LDL-C lowering agent and is safe and well tolerated. In response to significant controversy surrounding the use and therapeutic effectiveness of this drug, we provide an update on the biochemical mechanism of action for ezetimibe, its safety and efficacy, as well as the results of recent randomized studies that support its use in a variety of clinical scenarios.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Cholesterol 57-88-5 C27H46O 1167 suppliers $10.00-$71130.00
Ezetimibe 163222-33-1 C24H21F2NO3 732 suppliers $5.00-$1270.00

Similar articles

IF:4.4

Mechanism of action of 5-arninosalicylic acid.

Mediators of Inflammation N A Punchard, S M Greenfield,etc Published: 1 January 1992
IF:72.5

5-Fluorouracil: mechanisms of action and clinical strategies

Nature Reviews Cancer Daniel B. Longley, D. Paul Harkin,etc Published: 1 May 2003
IF:3.2

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

Phytochemistry Renuka Mani, Vijayakumar Natesan,etc Published: 1 January 2018
原平市| 嘉荫县| 凤庆县| 永丰县| 永昌县| 桑植县| 诸暨市| 西峡县| 清水县| 莱州市| 原平市| 万载县| 武山县| 沁阳市| 青铜峡市| 中江县| 静乐县| 日照市| 贞丰县| 高州市| 台中县| 博客| 永和县| 宿州市| 宾川县| 渭南市| 安阳县| 上虞市| 宝清县| 安塞县| 汉寿县| 阳春市| 南乐县| 弥渡县| 淮北市| 沙雅县| 金坛市| 陆良县| 西丰县| 沾益县| 河东区|