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AAPS PharmSciTech

AAPS PharmSciTech

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Control of Transdermal Permeation of Hydrocortisone Acetate from Hydrophilic and Lipophilic Formulations

Published:18 June 2008 DOI: 10.1208/s12249-008-9107-z PMID: 18563577
Adamo Fini, Valentina Bergamante, Gian Carlo Ceschel, Celestino Ronchi, Carlos Alberto Fonseca De Moraes

Abstract

The purpose of this research was the preparation of four formulations containing hydrocortisone acetate (HCA) for topical application, including two aqueous systems (hydrophilic microemulsion and aqueous gel) and two systems with dominant hydrophobicity (hydrophobic microemulsion and ointment). The formulations were tested for the release and permeation of HCA across an animal membrane. The release of HCA was found comparable for the four systems. The two microemulsions promote permeation across an ex-vivo membrane, examined by means of a Franz cell. Hydrophobic microemulsion guarantees the highest solubility (2,370?μg/ml) and flux (133?μg/cm2.h) of the drug, since it contains almost 40% Transcutol, a permeation enhancer. Gel and ointment provide lower solubility and flux, being the values, related to the ointment, the lowest ones (562?μg/ml and 0.4?μg/cm2.h). Experimental results allow the conclusion that gel and ointment can be suitable when it is desirable to minimize absorption of topically applied HCA as to keep the drug restricted to the diseased area and prevent side effects of the systemic presence of HCA.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Diethylene Glycol Monoethyl Ether 111-90-0 C6H14O3 725 suppliers $6.00-$1850.00
Hydrocortisone acetate 50-03-3 C23H32O6 640 suppliers $26.00-$2000.00

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