一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Neurogastroenterology and Motility >>article
Neurogastroenterology and Motility

Neurogastroenterology and Motility

IF: 3.5
Download PDF

Linaclotide - a secretagogue and antihyperalgesic agent - what next?

Published:1 March 2010 DOI: 10.1111/j.1365-2982.2009.01465.x PMID: 20377786
A E Bharucha, D R Linden

Abstract

Ongoing clinical trials suggest that linaclotide, a first-in-class, 14-amino acid peptide guanylate cyclase-C (GC-C) receptor agonist and intestinal secretagogue is an effective treatment for chronic constipation. A study in this issue of the Journal suggests that linaclotide also has antihyperalgesic effects in three common rat models of inflammation- and stress-induced hypersensitivity (i.e., acute trinitrobenzene sulfonic acid colitis, water avoidance stress [WAS], and restraint-induced stress) but not in na?ve animals. In mice, linaclotide at least partly reduces hyperalgesia via GC-C receptors. Dose-effect relationships of linaclotide were complicated and non-linear. This viewpoint discusses human clinical trials with linaclotide and the results of this study. Potential mechanisms and clinical significance of these findings are explored. Collectively, these data suggest that GC-C receptors exert other, as yet poorly understood, effects on gastrointestinal sensitivity in conditions associated with inflammation and/or stress-induced increased intestinal permeability. However, the data need to be confirmed in humans and in long-term animal models. Further studies are also necessary to elucidate the mechanisms as these effects cannot be explained by linaclotide's known effects on epithelial GC-C receptors.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Linaclotide 851199-59-2 C59H79N15O21S6 355 suppliers $32.00-$4023.90
2,4,6-TRINITROBENZENESULFONIC ACID 2508-19-2 C6H3N3O9S 18 suppliers $120.00-$1770.00
NPRC 9 suppliers Inquiry

Similar articles

IF:6.7

Phytochemicals: A potential next generation agent for radioprotection

Phytomedicine Bimal Prasad Jit , Subhaswaraj Pattnaik ,etc Published: 1 November 2022
IF:2.1

Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome.

American Journal of Health-System Pharmacy Bryan L Love, Audrey Johnson,etc Published: 1 July 2014
IF:5.4

Myrcene-What Are the Potential Health Benefits of This Flavouring and Aroma Agent?

ACS Applied Energy Materials Shelini Surendran,?Fatimah Qassadi,etc Published: 19 July 2021
拉萨市| 泌阳县| 垫江县| 肥城市| 肇庆市| 阿拉善盟| 麻栗坡县| 万载县| 图片| 门头沟区| 民县| 漯河市| 鄂伦春自治旗| 鄱阳县| 靖远县| 井冈山市| 马山县| 沾益县| 安西县| 银川市| 阿合奇县| 凌海市| 奈曼旗| 新和县| 梓潼县| 珠海市| 舟山市| 张家口市| 曲阳县| 平远县| 昆山市| 宜君县| 莱阳市| 洪泽县| 马关县| 五大连池市| 新沂市| 九龙坡区| 北安市| 邛崃市| 沽源县|