一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of veterinary pharmacology and therapeutics >>article
Journal of veterinary pharmacology and therapeutics

Journal of veterinary pharmacology and therapeutics

IF: 1.5
Download PDF

Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle).

Published:1 December 2012 DOI: 10.1111/j.1365-2885.2011.01349.x PMID: 22188102
M Menge, M Rose, C Bohland, E Zschiesche, S Kilp, W Metz, M Allan, R R?pke, M Nürnberger

Abstract

The pharmacokinetics of tildipirosin (Zuprevo(?) 180 mg/mL solution for injection for cattle), a novel 16-membered macrolide for treatment, control, and prevention of bovine respiratory disease, were investigated in studies collecting blood plasma, lung tissue, and in vivo samples of bronchial fluid (BF) from cattle. After single subcutaneous (s.c.) injection at 4 mg/kg body weight, maximum plasma concentration (C(max)) was 0.7 μg/mL. T(max) was 23 min. Mean residence time from the time of dosing to the time of last measurable concentration (MRT(last)) and terminal half-life (T(1/2) ) was 6 and 9 days, respectively. A strong dose-response relationship with no significant sex effect was shown for both C(max) and area under the plasma concentration-time curve from time 0 to the last sampling time with a quantifiable drug concentration (AUC(last) ) over the range of doses up to 6 mg/kg. Absolute bioavailability was 78.9%. The volume of distribution based on the terminal phase (V(z)) was 49.4 L/kg, and the plasma clearance was 144 mL/h/kg. The time-concentration profile of tildipirosin in BF and lung far exceeded those in blood plasma. In lung, tildipirosin concentrations reached 9.2 μg/g at 4 h, peaked at 14.8 μg/g at day 1, and slowly declined to 2.0 μg/g at day 28. In BF, the concentration of tildipirosin reached 1.5 and 3.0 μg/g at 4 and 10 h, maintained a plateau of about 3.5 μg/g between day 1 and 3, and slowly declined to 1.0 at day 21. T(1/2) in lung and BF was approximately 10 and 11 days. Tildipirosin is rapidly and extensively distributed to the respiratory tract followed by slow elimination.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Tildipirosin 328898-40-4 C41H71N3O8 209 suppliers $8.00-$2900.00

Similar articles

IF:1.5

Pharmacokinetics of tildipirosin in beagle dogs.

Journal of veterinary pharmacology and therapeutics J Wang, T Zhao,etc Published: 1 February 2018
IF:4.8

Pyrogallol, an active compound from the medicinal plant Emblica officinalis, regulates expression of pro-inflammatory genes in bronchial epithelial cells

International immunopharmacology Elena Nicolis , Ilaria Lampronti ,etc Published: 10 December 2008
IF:4.4

The Role of Trabectedin in Soft Tissue Sarcoma

Frontiers in Pharmacology Tomoki Nakamura,?A. Sudo,etc Published: 23 February 2022
小金县| 平昌县| 贡觉县| 万安县| 佛学| 靖江市| 湖北省| 山西省| 四平市| 富阳市| 乌鲁木齐市| 平度市| 铜鼓县| 金平| 沁水县| 吴江市| 丰顺县| 法库县| 修文县| 许昌县| 治多县| 清远市| 綦江县| 确山县| 镇平县| 金沙县| 丰顺县| 枣庄市| 双城市| 新津县| 宣恩县| 虎林市| 南华县| 澎湖县| 鸡泽县| 铜川市| 申扎县| 即墨市| 临邑县| 红桥区| 大渡口区|