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Expert opinion on medical diagnostics

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The role of thymidine kinase in cancer diseases.

Published:1 February 2008 DOI: 10.1517/17530059.2.2.129 PMID: 23485133
Ondrej Topolcan, Lubos Holubec

Abstract

Thymidine kinase 1 (TK 1-fetal) is a cell cycle-dependent marker that increases dramatically during the S-phase of the cell cycle. In this review, the authors discuss serum levels of thymidine kinase in a variety of neoplasias. Determination of thymidine kinase helps to monitor the follow-up of solid tumours and haematological malignancies as well as indicating the efficacy of adjuvant and palliative chemotherapy. Elevated levels of thymidine kinase must always be interpreted together with a detailed knowledge of the patient's condition because nonspecific elevations of serum levels (inflammatory and autoimmune diseases) must be excluded.

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