一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Drug and Chemical Toxicology >>article
Drug and Chemical Toxicology

Drug and Chemical Toxicology

IF: 2.1
Download PDF

Effects of a 28-day oral exposure to a 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one biocide formulation in Sprague-Dawley rats.

Published:1 April 2014 DOI: 10.3109/01480545.2013.834353 PMID: 24111717
Guillaume Pelletier, Victor E Valli, Marc Rigden, Raymond Poon

Abstract

Biocides are added to biodiesels to prevent degradation resulting from microbial growth. A 28-day repeated oral dose study was conducted to assess a potential risk arising from ingestion of isothiazolinone biocides in biodiesels. A mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (CMIT/MIT) diluted in corn oil was administered by gavage to male and female rats at 0, 0.26, 0.78, 2.33 and 7.0?mg/kg body weight per day. Rat water and food consumption was monitored. At the end of the dosing period, organs were weighed and histological examinations performed. Hematology, serum clinical chemistry and biomarkers of inflammation were assessed. Reduction of serum triglyceride levels in males and induction of hepatic phase 1 xenobiotic metabolizing enzymes in females accompanied by subtle histological changes in the liver were observed at the highest CMIT/MIT exposure. These changes were more indicative of an adaptive, reversible response than overt toxicity. Based on recommended levels for the control of microbial growth in fuels, CMIT/MIT contained in accidentally ingested biodiesels is not expected to represent a significant health risk.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
2-Methyl-4-isothiazolin-3-one 2682-20-4 C4H5NOS 548 suppliers $10.00-$800.00
5-Chloro-2-methyl-4-isothiazolin-3-one 26172-55-4 C4H4ClNOS 466 suppliers $15.00-$4161.85
CORN OIL 8001-30-7 N/A 300 suppliers $51.65-$531.00

Similar articles

IF:0.9

Antifungal activities of bronopol and 2-methyl-4-isothiazolin-3-one (MT) against saprolegnia.

Biocontrol science Heisuke Oono, Kishio Hatai,etc Published: 1 December 2007
IF:4.3

Acute effects of exposure to vapors of 3-methyl-1-butanol in humans.

Indoor air L Ernstg?rd, D Norb?ck,etc Published: 1 June 2013
汾西县| 华坪县| 印江| 葵青区| 南城县| 仪陇县| 仪陇县| 旌德县| 垣曲县| 德保县| 禄劝| 江门市| 鄢陵县| 临汾市| 宜春市| 汉中市| 通化县| 元阳县| 定结县| 娄烦县| 宜阳县| 方城县| 台山市| 德阳市| 花莲县| 天镇县| 竹北市| SHOW| 武强县| 阳曲县| 府谷县| 香港 | 平乐县| 怀柔区| 都安| 仁寿县| 炉霍县| 峡江县| 大连市| 广灵县| 广宁县|