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Journal of Medicinal Chemistry

Journal of Medicinal Chemistry

IF: 6.8
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Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Published:12 July 2012 DOI: 10.1021/jm3007323 PMID: 22784008
José Luis Díaz*, Rosa Cuberes, Joana Berrocal, Montserrat Contijoch, Ute Christmann, Ariadna Fernández, Adriana Port, J?rg Holenz, Helmut Buschmann, Christian Laggner, Maria Teresa Serafini, Javier Burgue?o, Daniel Zamanillo, Manuel Merlos, José Miguel Vela, Carmen Almansa

Abstract

The synthesis and pharmacological activity of a new series of 1-arylpyrazoles as potent σ1 receptor (σ1R) antagonists are reported. The new compounds were evaluated in vitro in human σ1R and guinea pig σ2 receptor (σ2R) binding assays. The nature of the pyrazole substituents was crucial for activity, and a basic amine was shown to be necessary, in accordance with known receptor pharmacophores. A wide variety of amines and spacer lengths between the amino and pyrazole groups were tolerated, but only the ethylenoxy spacer and small cyclic amines provided compounds with sufficient selectivity for σ1R vs σ2R. The most selective compounds were further profiled, and compound 28, 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862), which showed high activity in the mouse capsaicin model of neurogenic pain, emerged as the most interesting candidate. In addition, compound 28 exerted dose-dependent antinociceptive effects in several neuropathic pain models. This, together with its good physicochemical, safety, and ADME properties, led compound 28 to be selected as clinical candidate.

Synthesis

4-Chlorophenylhydrazine hydrochloride
Acrylamide
1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
S1RA 878141-96-9 C20H23N3O2 120 suppliers $44.00-$2691.10

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