一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Depression and Anxiety >>article
Depression and Anxiety

Depression and Anxiety

IF: 4.7
Download PDF

d-CYCLOSERINE FOR TREATING ANXIETY DISORDERS: MAKING GOOD EXPOSURES BETTER AND BAD EXPOSURES WORSE

Published:22 February 2014 DOI: 10.1002/da.22257 PMID: 24677604
Stefan G. Hofmann Ph.D.

Abstract

In an attempt to improve the efficacy of psychotherapy for anxiety disorders, preclinical paradigms have recent been translated into novel treatment strategies.[1] Specifically, these studies have examined the role of glutamate, an excitatory neurotransmitter in the mammalian brain, in extinction learning. A receptor complex involved in this process is the N-methyl-D-aspartate (NMDA) receptor. Activation of the NMDA receptor requires binding of both glutamate and the co-agonist glycine. D-cycloserine (D-4-amino-3-isoxazolidone; DCS) is a partial agonist at the glycine recognition site of the glutamatergic NMDA receptor. Animal studies that employed fear-potentiated startle to a conditioned stimulus have demonstrated that this substance can augment extinction learning in rats.[1] The result of this translational work has shown for some studies that DCS can act as a cognitive enhancer to augment exposure strategies during cognitive-behavioral therapy of anxiety disorders.[2] This line of research has gathered a significant amount of attention because it is a prime example of translational research, whereby basic neuroscience directly informs clinical science by identifying a compound and mechanism of treatment change. Following the initial excitement surrounding early DCS augmentation trials, a number of studies have been conducted that provide a more refined picture. These studies further have clarified some of the limitations and indications of DCS as an augmentation strategy.

Substances (5)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Glycine 56-40-6 C2H5NO2 1876 suppliers $5.00-$39560.00
D-Cycloserine 68-41-7 C3H6N2O2 668 suppliers $5.00-$3346.00
N-Methyl-D-aspartic acid 6384-92-5 C5H9NO4 349 suppliers $8.00-$3330.00
Glutamate 7528-09-8 14 suppliers Inquiry
DCS cells 7 suppliers Inquiry

Similar articles

IF:6.5

From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health1

American Journal of Clinical Nutrition Anthony W Norman,etc Published: 1 August 2008
IF:4.5

D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review.

International Journal of Neuropsychopharmacology Sebastian Schade, Walter Paulus,etc Published: 20 April 2016
IF:5.8

D-Cycloserine enhances the bidirectional range of NMDAR-dependent hippocampal synaptic plasticity.

Translational Psychiatry Stefan Vestring,?Alexandra Dorner,etc Published: 9 January 2024
仁化县| 景德镇市| 甘南县| 独山县| 康马县| 远安县| 抚顺县| 阳高县| 珠海市| 普陀区| 余干县| 汉阴县| 南宫市| 临泉县| 广饶县| 浦县| 兴隆县| 万年县| 徐闻县| 湖北省| 桐梓县| 从江县| 恩平市| 铜陵市| 鄂托克旗| 兴安盟| 三明市| 本溪| 武隆县| 民县| 广西| 平南县| 霸州市| 思茅市| 长海县| 湄潭县| 保定市| 四会市| 德钦县| 抚松县| 达日县|