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ACS Applied Bio Materials

ACS Applied Bio Materials

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Effect of sodium benzoate preservative on micronucleus induction, chromosome break, and Ala40Thr superoxide dismutase gene mutation in lymphocytes.

Published:1 January 2015 DOI: 10.1155/2015/103512 PMID: 25785261
Malinee Pongsavee

Abstract

Sodium benzoate is food preservative that inhibits microbial growth. The effects of sodium benzoate preservative on micronucleus induction, chromosome break, and Ala40Thr superoxide dismutase gene mutation in lymphocytes were studied. Sodium benzoate concentrations of 0.5, 1.0, 1.5, and 2.0?mg/mL were treated in lymphocyte cell line for 24 and 48?hrs, respectively. Micronucleus test, standard chromosome culture technique, PCR, and automated sequencing technique were done to detect micronucleus, chromosome break, and gene mutation. The results showed that, at 24- and 48-hour. incubation time, sodium benzoate concentrations of 1.0, 1.5, and 2.0?mg/mL increased micronucleus formation when comparing with the control group (P < 0.05). At 24- and 48-hour. incubation time, sodium benzoate concentrations of 2.0?mg/mL increased chromosome break when comparing with the control group (P < 0.05). Sodium benzoate did not cause Ala40Thr (GCG→ACG) in superoxide dismutase gene. Sodium benzoate had the mutagenic and cytotoxic toxicity in lymphocytes caused by micronucleus formation and chromosome break.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Sodium benzoate 532-32-1 C7H5NaO2 1577 suppliers $5.00-$2285.00
Superoxide dismutase 9054-89-1 NULL 471 suppliers $61.90-$3720.00

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