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AAPS PharmSciTech

AAPS PharmSciTech

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A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for Efficient Ophthalmic Delivery of Pilocarpine Nitrate

Published:2 January 2019 DOI: 10.1208/s12249-018-1248-0 PMID: 30603986
Xingqi Wang, Yong Zhang, Jie Huang, Chunling Tian, Mengqiu Xia, Liu Liu, Zhengguang Li, Jiaojiao Cao, Shuangying Gui, Xiaoqin Chu

Abstract

The purpose of this paper was to investigate the potential of liquid crystalline (LC) gels for ophthalmic delivery, so as to enhance the bioavailability of pilocarpine nitrate (PN). The gels were prepared by a vortex method using phytantriol and water (in the ratio of 73:27 w/w). Their inner structures were confirmed by crossed polarized light microscopy, small-angle X-ray scattering, attenuated total reflectance-Fourier transform infrared spectrum, and rheology. The in vitro release studies revealed that PN could keep sustained release from the gels over a period of 12?h. The ex vivo apparent permeability coefficient of the gels demonstrated a 3.83-folds (P?<?0.05) increase compared with that of eye drops. The corneal hydration levels of the gel maintained in the normal range of 79.46?±?2.82%, hinting that the gel could be considered non-damaging and safe to the eyes. Furthermore, in vivo residence time evaluation suggested that a better retention performance of LC gel was observed in rabbit’s eyes compared to eye drops. In vivo ocular irritation study indicated that LC gel was nonirritant and might be suitable for various eye applications. In conclusion, LC gels might represent a potential ophthalmic delivery strategy to overcome the limitations of eye drops.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00

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