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Food & Function

Food & Function

IF: 5.1
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Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii

Published:13 June 2018 DOI: 10.1039/C8FO00604K PMID: 29897364
Qiuhui Hu, Hengjun Du, Gaoxing Ma, Fei Pei, Ning Ma, Biao Yuan, Paul A. Nakata and Wenjian Yang

Abstract

Pleurotus eryngii contains bioactive compounds that can activate the immune system. Here we report the identification, purification, and functional characterization of the bioactive P. eryngii protein (PEP) 1b. PEP 1b was discovered to be a 21.9 kDa protein with the ability to induce the M1-polarization of the macrophage cell line RAW 264.7 cells. Biochemical measurements showed that PEP 1b stimulated nitric oxide (NO), IL-1β, IL-6 and TNF-α production and regulated inducible NO synthase. Phosphorylation and inhibitor studies revealed that PEP 1b promoted the translocation of NF-kB from the cytosol to the nucleus allowing the induction of target gene expression and NO production. The phosphorylation of JNK and ERK1/2 was found to be necessary for NO production. Each phosphorylation pathway was found to require a Toll-like receptor (TLR) 4 as a prerequisite for PEP 1b-induced NO production. This study suggests that PEP 1b is an immunomodulatory protein that can boost cellular immune responses through the activation of the TLR4-NF-κB and MAPK signaling pathways.

Substances (28)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Polymyxin B sulfate 1405-20-5 C56H100N16O17S 724 suppliers $27.00-$8320.00
Polymyxin B sulfate 1405-20-5 C56H100N16O17S 724 suppliers $27.00-$8320.00
Polymyxin B sulfate 1405-20-5 C56H100N16O17S 724 suppliers $27.00-$8320.00
Polymyxin B sulfate 1405-20-5 C56H100N16O17S 724 suppliers $27.00-$8320.00
SB 203580 152121-47-6 C21H16FN3OS 317 suppliers $16.00-$2151.00
SB 203580 152121-47-6 C21H16FN3OS 317 suppliers $16.00-$2151.00
SB 203580 152121-47-6 C21H16FN3OS 317 suppliers $16.00-$2151.00
SB 203580 152121-47-6 C21H16FN3OS 317 suppliers $16.00-$2151.00
1,9-Pyrazoloanthrone 129-56-6 C14H8N2O 290 suppliers $5.00-$1390.00
1,9-Pyrazoloanthrone 129-56-6 C14H8N2O 290 suppliers $5.00-$1390.00

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