一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Antiviral research >>article
Antiviral research

Antiviral research

IF: 4.5
Download PDF

The antifungal isavuconazole inhibits the entry of lassa virus by targeting the stable signal peptide-GP2 subunit interface of lassa virus glycoprotein

Published:1 February 2020 DOI: 10.1016/j.antiviral.2019.104701 PMID: 31877348
Xiaoyu Zhang , Ke Tang , Ying Guo

Abstract

Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever in humans, and the limited therapeutic treatment for Lassa fever poses significant threat to public health in West Africa. Using an HIV based pseudovirus platform, we identified isavuconazole, a triazole antifungal for systemic use, as a LASV entry inhibitor with an EC50 of 1.2?μM. Isavuconazole inhibits Lassa virus entry by blocking the pH dependent viral fusion mediated by the Lassa virus surface glycoprotein. Fragment replacement mutational study indicated that isavuconazole targets the stable signal peptide (SSP)-membrane fusion subunit (GP2) interface of Lassa glycoprotein. Further mutational study of the SSP-GP2 region of LASV glycoprotein revealed that S27 in the N-terminal transmembrane region of SSP and V431, F434 and V435 in the transmembrane domain of GP2 affect anti-LASV activity of isavuconazole. Isavuconazole also displays antiviral activity to five New World (NW) mammarenaviruses that cause hemorrhagic fever. This study facilitates the potential repurposing of isavuconazole for therapeutic intervention against human-pathogenic arenaviruses, and provides the basis for further structural optimization of arenavirus fusion inhibitors based on the predicted structural characteristics of the unique SSP-GP2 interface.

Similar articles

IF:4.3

Escape from human immunodeficiency virus type 1 (HIV-1) entry inhibitors.

ACS Applied Electronic Materials Christopher J De Feo, Carol D Weiss,etc Published: 1 December 2012
IF:4.6

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir.

Clinical Pharmacokinetics Brian J Kirby, William T Symonds,etc Published: 1 July 2015
IF:0

Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.

Current opinion in investigational drugs Alessandro C Pasqualotto, Karoline O Thiele,etc Published: 1 February 2010
乐安县| 隆回县| 噶尔县| 揭东县| 天柱县| 新邵县| 新竹市| 西林县| 扶余县| 蒙自县| 淮阳县| 咸阳市| 福州市| 大姚县| 长海县| 景泰县| 岗巴县| 汾西县| 沾化县| 剑川县| 册亨县| 体育| 宁海县| 叙永县| 富源县| 和硕县| 商都县| 和顺县| 澜沧| 太原市| 深圳市| 翁源县| 谷城县| 阿尔山市| 丰县| 农安县| 财经| 广河县| 新津县| 霍林郭勒市| 犍为县|