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Current opinion in investigational drugs

Current opinion in investigational drugs

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Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.

Published:1 February 2010 DOI: PMID: 20112166
Alessandro C Pasqualotto, Karoline O Thiele, Luciano Z Goldani

Abstract

Azoles are important compounds for the treatment of fungal infections. This review focuses on three azoles: isavuconazole, ravuconazole and albaconazole (Stiefel). These drugs exhibit a broad spectrum of activity in vitro, including activity against several fungal isolates that are resistant to other azoles. However, poor or limited activity of these compounds has been demonstrated against species of Fusarium and Scedosporium, as well as against Zygomycetes. As isavuconazole and ravuconazole have been developed both as intravenous and oral formulations, these compounds are suitable candidates for the treatment of various invasive fungal diseases. Most clinical trials with albaconazole have targeted mucocutaneous fungal infections. Although all of these agents appear to be well tolerated, cross-resistance is a concern in the azole family of compounds.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Isavuconazole 241479-67-4 C22H17F2N5OS 375 suppliers $8.00-$1800.00
Ravuconazole 182760-06-1 C22H17F2N5OS 122 suppliers $44.00-$636.00
Albaconazole 187949-02-6 C20H16ClF2N5O2 44 suppliers $200.00-$3000.00
Ravuconazole 170864-29-6 C22H17F2N5OS 36 suppliers Inquiry
ALBACONAZOLE 206350-10-9 C20H16ClF2N5O2 2 suppliers Inquiry
RAVUCONAZOLE 194798-96-4 C22H17F2N5OS 2 suppliers Inquiry

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