一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> CNS Neuroscience & Therapeutics >>article
CNS Neuroscience & Therapeutics

CNS Neuroscience & Therapeutics

IF: 4.8
Download PDF

Quetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair

Published:22 July 2013 DOI: 10.1111/cns.12154 PMID: 23870612
Simon Zhornitsky, Voon Wee Yong, Marcus W. Koch, Aaron Mackie, Stéphane Potvin, Scott B. Patten, Luanne M. Metz

Abstract

Multiple sclerosis (MS) is a central nervous system disorder that is associated with progressive oligodendrocyte and neuronal loss, axonal degeneration, and demyelination. Several medications that mitigate immune abnormalities reduce both the frequency of relapses and inflammation on magnetic resonance imaging, leading to improved outcomes for people with the relapsing–remitting form of MS. However, there are no treatments for the progressive forms of MS where neurons and axons continue to degenerate; here, neuroprotective therapies, or medications that rebuild myelin to confer axonal well-being, may be useful. Quetiapine fumarate is an atypical antipsychotic with reported remyelinating and neuroprotective properties in inflammatory and noninflammatory models of demyelination, including experimental autoimmune encephalomyelitis, and both cuprizone- and global cerebral ischemia-induced demyelination. Preclinical studies suggest that quetiapine may exert these effects by stimulating proliferation and maturation of oligodendrocytes, releasing neurotrophic factors, increasing antioxidant defences, scavenging for free radicals, and inhibiting activated microglia, astrocytes, and T lymphocytes. Additionally, quetiapine may be beneficial for psychiatric and nonpsychiatric symptoms of MS including depression, anxiety, insomnia, and possibly even pain. These data indicate that clinical trials are justified to determine the safety, tolerability, and efficacy of quetiapine fumarate in MS.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Quetiapine fumarate 111974-72-2 C25H29N3O6S 823 suppliers $25.00-$1963.50
Bis(cyclohexanone)oxaldihydrazone 370-81-0 C14H22N4O2 269 suppliers $8.00-$826.48

Similar articles

IF:4.2

Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases.

Molecules Yan He,?Yi Wang,etc Published: 9 December 2022
IF:0

Single- and Multiple-Dose Pharmacokinetics of Dapoxetine Hydrochloride, a Novel Agent for the Treatment of Premature Ejaculation

The Journal of Clinical Pharmacology Nishit B. Modi PhD, Mark J. Dresser PhD,etc Published: 8 March 2013
IF:3.4

Understanding variability in the pharmacokinetics of atypical antipsychotics - focus on clozapine, olanzapine and aripiprazole population models.

Drug Metabolism Reviews Marija Jovanovi?, Katarina Vu?i?evi?,etc Published: 1 February 2020
叶城县| 吉林市| 海林市| 南江县| 永州市| 普宁市| 北辰区| 甘洛县| 永嘉县| 公主岭市| 建水县| 巴东县| 日照市| 集贤县| 布尔津县| 临沧市| 林周县| 永修县| 明水县| 白城市| 东港市| 兴安县| 荣成市| 新河县| 五河县| 江门市| 浦江县| 南充市| 宜都市| 宜城市| 巴青县| 额敏县| 耿马| 留坝县| 遂溪县| 东阳市| 阿鲁科尔沁旗| 连州市| 客服| 沁源县| 磴口县|