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CNS Neuroscience & Therapeutics

CNS Neuroscience & Therapeutics

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Quetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair

Published:22 July 2013 DOI: 10.1111/cns.12154 PMID: 23870612
Simon Zhornitsky, Voon Wee Yong, Marcus W. Koch, Aaron Mackie, Stéphane Potvin, Scott B. Patten, Luanne M. Metz

Abstract

Multiple sclerosis (MS) is a central nervous system disorder that is associated with progressive oligodendrocyte and neuronal loss, axonal degeneration, and demyelination. Several medications that mitigate immune abnormalities reduce both the frequency of relapses and inflammation on magnetic resonance imaging, leading to improved outcomes for people with the relapsing–remitting form of MS. However, there are no treatments for the progressive forms of MS where neurons and axons continue to degenerate; here, neuroprotective therapies, or medications that rebuild myelin to confer axonal well-being, may be useful. Quetiapine fumarate is an atypical antipsychotic with reported remyelinating and neuroprotective properties in inflammatory and noninflammatory models of demyelination, including experimental autoimmune encephalomyelitis, and both cuprizone- and global cerebral ischemia-induced demyelination. Preclinical studies suggest that quetiapine may exert these effects by stimulating proliferation and maturation of oligodendrocytes, releasing neurotrophic factors, increasing antioxidant defences, scavenging for free radicals, and inhibiting activated microglia, astrocytes, and T lymphocytes. Additionally, quetiapine may be beneficial for psychiatric and nonpsychiatric symptoms of MS including depression, anxiety, insomnia, and possibly even pain. These data indicate that clinical trials are justified to determine the safety, tolerability, and efficacy of quetiapine fumarate in MS.

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Procduct Name CAS Molecular Formula Supplier Price
Quetiapine fumarate 111974-72-2 C25H29N3O6S 823 suppliers $25.00-$1963.50
Bis(cyclohexanone)oxaldihydrazone 370-81-0 C14H22N4O2 269 suppliers $8.00-$826.48

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