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Cellular immunology

Cellular immunology

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Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo

Published:1 March 2020 DOI: 10.1016/j.cellimm.2020.104046 PMID: 32057354
Yuanyuan Chen , Ruisheng Li , Zhilei Wang , Xiaorong Hou , Chunyu Wang , Yongqiang Ai , Wei Shi , Xiaoyan Zhan , Jia-bo Wang , Xiaohe Xiao , Zhaofang Bai , Hongsheng Sun , Guang Xu

Abstract

Uncontrolled activation of NLRP3 inflammasome initiates a series of human inflammatory diseases. Targeting NLRP3 inflammasome has attracted considerable attention in developing potential therapeutic interventions. Here, we reported that dehydrocostus lactone (DCL), a main component of Saussurea lappa from the traditional Chinese medicine, inhibited NLRP3 inflammasome-mediated caspase-1 activation and subsequent interleukin (IL)-1β production in primary mouse macrophages and human peripheral blood mononuclear cells and exerted an inhibitory effect on NLRP3-driven inflammation. Mechanistically, DCL significantly blocked the ASC oligomerization, which is essential for the assembly of activated inflammasome. Importantly, in vivo experiments showed that DCL reduced IL-1β secretion and peritoneal neutrophils recruitment in LPS-mediated inflammation mouse model, which is demonstrated to be NLRP3 dependent. These results suggest that DCL is a potent pharmacological inhibitor of NLRP3 inflammasome and may be developed as a therapeutic drug for treating NLRP3-associated diseases.

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Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Dehydrocostus lactone 477-43-0 C15H18O2 290 suppliers $10.00-$1267.00
Dehydrocostus lactone 477-43-0 C15H18O2 290 suppliers $10.00-$1267.00
Dehydrocostus lactone 477-43-0 C15H18O2 290 suppliers $10.00-$1267.00
Dehydrocostus lactone 477-43-0 C15H18O2 290 suppliers $10.00-$1267.00

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