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Biomaterials Science

Biomaterials Science

IF: 5.7
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A carrier free photodynamic oxidizer for enhanced tumor therapy by redox homeostasis disruption

Published:4 February 2022 DOI: 10.1039/D1BM01876K PMID: 35179530
Ni Yang, Rong-Rong Zheng, Zi-Ying Chen, Rui-Xin Wang, Lin-Ping Zhao, Xia-Yun Chen, Lei Chen, Lin Xu, Shi-Ying Li and A-Li Chen

Abstract

Abnormal tumor microenvironments play important roles in cancer progression. In general, tumor cells are capable of upregulating glutathione (GSH) levels to maintain aberrant redox homeostasis and cause resistance to oxidative damage. Herein, we develop a photodynamic oxidizer to disrupt the redox homeostasis of tumor cells for enhanced photodynamic tumor therapy. Based on pyropheophorbide-a (Pyro) and naphthazarin (Nap), a carrier free photodynamic oxidizer (named PyroNap) is prepared by the self-assembly technique through hydrophobic interactions. It is confirmed that nanosized PyroNap has high drug contents as well as favorable dispersity and stability. Besides, the photodynamic property of Pyro has obviously improved after self-assembly into the nanomedicine of PyroNap, which facilitates the production of reactive oxygen species (ROS) for robust photodynamic therapy (PDT). More importantly, the Nap induced GSH decrease could disrupt the redox homeostasis of tumor cells to further improve the PDT efficacy on tumor suppression. Consequently, after intravenous administration, PyroNap was able to significantly inhibit tumor growth and cause minimal side effects. This study might shed light on developing translational nanomedicine for tumor precision therapy.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
5,8-Dihydroxy-1,4-naphthoquinone 475-38-7 C10H6O4 157 suppliers $44.00-$1285.00
5,8-Dihydroxy-1,4-naphthoquinone 475-38-7 C10H6O4 157 suppliers $44.00-$1285.00
5,8-Dihydroxy-1,4-naphthoquinone 475-38-7 C10H6O4 157 suppliers $44.00-$1285.00
5,8-Dihydroxy-1,4-naphthoquinone 475-38-7 C10H6O4 157 suppliers $44.00-$1285.00

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