一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Biomaterials Science >>article
Biomaterials Science

Biomaterials Science

IF: 5.7
Download PDF

A self-assembling CXCR4-targeted pyroptosis nanotoxin for melanoma therapy

Published:25 January 2023 DOI: 10.1039/D2BM02026B PMID: 36745434
Zheng Zhao, Yingbin Huang, Jing Wang, Hongsheng Lin, Fei Cao, Shuxin Li, Yin Li, Ziqian Li and Xuekui Liu

Abstract

While immunotherapy has emerged as a promising strategy to treat melanoma, the limited availability of immunotherapeutic agents in tumors due to the immunosuppressive tumor microenvironment dampens its efficacy. Pyroptosis is a gasdermin-mediated programmed necrosis that triggers the inflammatory tumor microenvironment and enhances the efficacy of tumor immunotherapy. Here, we prove that the CXCR4 antagonist T22 peptide specially targeted and became internalized into CXCR4+ melanoma cells. Then we report a self-assembling nanotoxin that can be used to spatiotemporally target CXCR4-expression melanoma cells and enable tunable cellular pyroptosis. Specific activation of caspase 3 signal transduction triggers gasdermin-E-mediated pyroptosis. This nanotoxin induces pyroptotic cell death resulting in enhanced antitumor efficacy and minimized systemic side effects toward melanoma in vivo. This study offers new insights into how to engineer nanotoxins with tunable pyroptosis activity through specifically targeting CXCR4 for biomedical applications.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Crystal Violet 548-62-9 C25H30ClN3 874 suppliers $5.00-$2290.00

Similar articles

IF:3

A comprehensive review on Brigatinib – A wonder drug for targeted cancer therapy in non-small cell lung cancer

Saudi Pharmaceutical Journal Silky Bedi , Shah A. Khan ,etc Published: 1 September 2018
IF:10.5

Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer

Journal of Controlled Release Wei Ran , Xiaoyu Liu ,etc Published: 1 February 2020
IF:3.5

Quinoline Endoperoxides for Mitochondria Targeted Singlet Oxygen Delivery

Chemistry - An Asian Journal Yu Si, Lei Wang,etc Published: 29 November 2024
元阳县| 临颍县| 乌拉特前旗| 商南县| 手游| 金溪县| 垦利县| 佛教| 崇左市| 荥阳市| 云和县| 边坝县| 大兴区| 团风县| 东方市| 平定县| 凯里市| 顺昌县| 理塘县| 家居| 手游| 开鲁县| 诸暨市| 长寿区| 贺州市| 且末县| 循化| 萨嘎县| 大姚县| 浪卡子县| 新闻| 六盘水市| 聂荣县| 邵东县| 藁城市| 泸西县| 化州市| 大冶市| 敖汉旗| 溆浦县| 高雄市|