一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> FEBS Open Bio >>article
FEBS Open Bio

FEBS Open Bio

IF: 2.8
Download PDF

Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression

Published:12 September 2021 DOI: 10.1002/2211-5463.13298 PMID: 34510826
Zhuoli Yang, Hua Liu, Ran Song, Wenxiu Lu, Haibo Wang, Siyu Gu, Xuedi Cao, Yibin Chen, Jihuan Liang, Qiong Qin, Xiaomei Yang, Duiping Feng, Junqi He

Abstract

Human papillomavirus type 18 (HPV18) has high carcinogenic power in invasive cervical cancer (ICC) development. However, the underlying mechanism remains elusive. The carcinogenic properties of HPV18 require the PDZ-binding motif of its E6 oncoprotein (HPV18 E6) to degrade its target PSD95/Dlg/ZO-1 (PDZ) proteins. In this study, we demonstrated that the PDZ protein membrane-associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) inhibited the Wnt/β-catenin pathway, and subsequently cervical cancer (CC) cell migration and invasion, via decreasing β-catenin levels. By reducing MAGI3 protein levels, HPV18 E6 promoted CC cell migration and invasion through activation of Wnt/β-catenin signaling. Furthermore, HPV18 rather than HPV16 was preferentially associated with the downregulation of MAGI3 and activation of the Wnt/β-catenin pathway in CC. These findings shed light on the mechanism that gives HPV18 its high carcinogenic potential in CC progression.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00

Similar articles

IF:4.5

Antimicrobial agent chloroxylenol targets β?catenin?mediated Wnt signaling and exerts anticancer activity in colorectal cancer.

International journal of oncology Qi Sun, Boxin Liu,etc Published: 1 November 2023
IF:5.6

D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-β signaling pathway

Food Science and Human Wellness Chong Wang, Fangting Wang,etc Published: 1 September 2022
抚宁县| 绩溪县| 济源市| 潞西市| 额尔古纳市| 囊谦县| 晴隆县| 佛坪县| 泉州市| 昌乐县| 喀喇沁旗| 英山县| 明溪县| 铜鼓县| 新泰市| 张家川| 永德县| 沈丘县| 湟中县| 安康市| 乌鲁木齐市| 峡江县| 长沙市| 礼泉县| 武陟县| 资中县| 霍城县| 都兰县| 大理市| 阿瓦提县| 南昌市| 汉寿县| 招远市| 隆安县| 如皋市| 临湘市| 高唐县| 神木县| 东光县| 滦南县| 丹巴县|