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ACS Applied Bio Materials

ACS Applied Bio Materials

IF: 4.6
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WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2

Published:8 October 2021 DOI: 10.7717/peerj.12262 PMID: 34707939
Luiz Guilherme H S Arag?o,?Júlia T Oliveira,?Jairo R Temerozo,?Mayara A Mendes,?José Alexandre Salerno,?Carolina S G Pedrosa,?Teresa Puig-Pijuan,?Carla P Veríssimo,?Isis M Ornelas,?Thayana Torquato,?Gabriela Vitória,?Carolina Q Sacramento,?Natalia Fintelman-Rodrigues,?Suelen da Silva Gomes Dias,?Vinicius Cardoso Soares,?Letícia R Q Souza,?Karina Karmirian,?Livia Goto-Silva,?Diogo Biagi,?Estela M Cruvinel,?Rafael Dariolli,?Daniel R Furtado,?Patrícia T Bozza,?Helena L Borges,?Thiago M L Souza,?Marília Zaluar P Guimar?es,?Stevens K Rehen

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can infect several organs, especially impacting respiratory capacity. Among the extrapulmonary manifestations of COVID-19 is myocardial injury, which is associated with a high risk of mortality. Myocardial injury, caused directly or indirectly by SARS-CoV-2 infection, can be triggered by inflammatory processes that lead to damage to the heart tissue. Since one of the hallmarks of severe COVID-19 is the "cytokine storm", strategies to control inflammation caused by SARS-CoV-2 infection have been considered. Cannabinoids are known to have anti-inflammatory properties by negatively modulating the release of pro-inflammatory cytokines. Herein, we investigated the effects of the cannabinoid agonist WIN 55,212-2 (WIN) in human iPSC-derived cardiomyocytes (hiPSC-CMs) infected with SARS-CoV-2. WIN did not modify angiotensin-converting enzyme II protein levels, nor reduced viral infection and replication in hiPSC-CMs. On the other hand, WIN reduced the levels of interleukins six, eight, 18 and tumor necrosis factor-alpha (TNF-α) released by infected cells, and attenuated cytotoxic damage measured by the release of lactate dehydrogenase (LDH). Our findings suggest that cannabinoids should be further explored as a complementary therapeutic tool for reducing inflammation in COVID-19 patients.

Substances (5)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
WIN 55,212-2 MESYLATE 131543-23-2 C28H30N2O6S 167 suppliers $46.00-$2023.00
WIN 55,212-2 MESYLATE 131543-23-2 C28H30N2O6S 167 suppliers $46.00-$2023.00
WIN 55,212-2 MESYLATE 131543-23-2 C28H30N2O6S 167 suppliers $46.00-$2023.00
WIN 55,212-2 MESYLATE 131543-23-2 C28H30N2O6S 167 suppliers $46.00-$2023.00

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