一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> ACS Applied Bio Materials >>article
ACS Applied Bio Materials

ACS Applied Bio Materials

IF: 4.6
Download PDF

Manganese chloride tetrahydrate (CMC-001) enhanced liver MRI: evaluation of efficacy and safety in healthy volunteers.

Published:1 October 2012 DOI: 10.1007/s10334-012-0307-x PMID: 22399275
Nils Albiin, Nikolaos Kartalis, Annika Bergquist, Bita Sadigh, Torkel B Brismar

Abstract

Object: To evaluate the efficacy of three dose levels of the oral hepatobiliary manganese-based magnetic resonance imaging (MRI) contrast agent CMC-001, and assess its safety profile and patient acceptability.

Materials and methods: After ethics committee approval, 32 healthy volunteers (males/females: 18/14) were included. Liver MRI was performed before and 3 h after ingestion of 0.8, 0.4, and 0.2 g of CMC-001 on separate occasions. Liver-to-muscle signal intensity (SI) ratio from baseline to post-contrast and image quality was assessed. Adverse drug reactions/adverse events (ADRs/AEs) and clinico-laboratory tests were monitored.

Results: The increase in liver-to-muscle SI ratio was significantly higher after 0.8 g (0.696) compared to 0.4 g (0.458) and 0.2 g (0.223) (in all pair-wise comparisons, P < 0.0001). The overall image quality was superior after 0.8 g. ADRs/AEs were dose-related and predominantly of mild intensity.

Conclusion: Liver MRI using 0.8 g CMC-001 has the highest efficacy and still acceptable ADRs and should therefore be preferred.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Manganese chloride tetrahydrate 13446-34-9 Cl2H2MnO 496 suppliers $7.62-$5590.00
福安市| 阳原县| 柘城县| 吉安市| 逊克县| 页游| 石屏县| 九江县| 兰州市| 兰考县| 玉树县| 西盟| 长岛县| 怀集县| 东光县| 大安市| 南岸区| 深圳市| 汉源县| 额敏县| 泸水县| 靖远县| 文山县| 镇巴县| 耒阳市| 肥东县| 桦甸市| 洱源县| 莒南县| 张北县| 石门县| 蛟河市| 巴南区| 阜阳市| 佛教| 友谊县| 开江县| 通州区| 康定县| 甘孜| 昌邑市|