一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cells >>article
Cells

Cells

IF: 5.2
Download PDF

Methyltransferase Setdb1 Promotes Osteoblast Proliferation by Epigenetically Silencing Macrod2 with the Assistance of Atf7ip

Published:19 August 2022 DOI: 10.3390/cells11162580 PMID: 36010655
Lijun Zhang,?Liqun Xu,?Xiaoyan Zhang,?Ke Wang,?Yingjun Tan,?Gaozhi Li,?Yixuan Wang,?Tong Xue,?Quan Sun,?Xinsheng Cao,?Ge Zhang,?Zebing Hu,?Shu Zhang,?Fei Shi

Abstract

Bone loss caused by mechanical unloading is a threat to prolonged space flight and human health. Epigenetic modifications play a crucial role in varied biological processes, but the mechanism of histone modification on unloading-induced bone loss has rarely been studied. Here, we discovered for the first time that the methyltransferase Setdb1 was downregulated under the mechanical unloading both in vitro and in vivo so as to attenuate osteoblast proliferation. Furthermore, we found these interesting processes depended on the repression of Macrod2 expression triggered by Setdb1 catalyzing the formation of H3K9me3 in the promoter region. Mechanically, we revealed that Macrod2 was upregulated under mechanical unloading and suppressed osteoblast proliferation through the GSK-3β/β-catenin signaling pathway. Moreover, Atf7ip cooperatively contributed to osteoblast proliferation by changing the localization of Setdb1 under mechanical loading. In summary, this research elucidated the role of the Atf7ip/Setdb1/Macrod2 axis in osteoblast proliferation under mechanical unloading for the first time, which can be a potential protective strategy against unloading-induced bone loss.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Bortezomib 179324-69-7 C19H25BN4O4 849 suppliers $10.00-$1980.00
Bortezomib 179324-69-7 C19H25BN4O4 849 suppliers $10.00-$1980.00
Bortezomib 179324-69-7 C19H25BN4O4 849 suppliers $10.00-$1980.00
Bortezomib 179324-69-7 C19H25BN4O4 849 suppliers $10.00-$1980.00
Bortezomib 179324-69-7 - Inquiry
Bortezomib 179324-69-7 - Inquiry
Bortezomib 179324-69-7 - Inquiry
Bortezomib 179324-69-7 - Inquiry

Similar articles

东海县| 内乡县| 渝中区| 京山县| 嵊州市| 府谷县| 盖州市| 白玉县| 交城县| 松滋市| 通渭县| 屏边| 府谷县| 彭泽县| 抚州市| 团风县| 江油市| 略阳县| 昭觉县| 和静县| 腾冲县| 大邑县| 岑溪市| 寿光市| 阿城市| 云南省| 抚松县| 白水县| 汕头市| 鹰潭市| 黄龙县| 卢湾区| 弥渡县| 阿巴嘎旗| 珲春市| 麻栗坡县| 金华市| 越西县| 新龙县| 墨脱县| 福贡县|