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ACS Applied Bio Materials

ACS Applied Bio Materials

IF: 4.6
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Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer

Published:3 November 2022 DOI: 10.1155/2022/6207701 PMID: 36389117
Aozheng Chen,?Min Xu,?Jing Chen,?Tingting Chen,?Qin Wang,?Runjie Zhang,?Jin Qiu

Abstract

High-risk human papillomavirus (HR-HPV) is the main etiological factor for cervical cancer. Accumulating evidence has suggested the active role of metabolites in the initiation and progression of cancers. This study explored the plasma metabolic profiles of HPV-16 positive (HPV16 (+)), HPV-18 positive (HPV18 (+)), and HPV negative (CTL) individuals using a nontargeted metabolomics approach. C8 ceramide-1-Phosphate (d18?:?1/8?:?0) was found to inhibit cervical cancer cell proliferation and migration in vitro, evidenced by CCK8 experiments, a cell migration test, RT-qPCR, and western blotting. The underlying mechanism demonstrated that C8 inhibited proliferation and migration in cervical cancer cells via the MAPK/JNK1 signaling pathway. These findings may contribute to the clinical treatment of HR-HPV-induced cervical cancer by intervening in its initiation and progression.

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Procduct Name CAS Molecular Formula Supplier Price
C8 CERAMIDE 74713-59-0 C26H51NO3 138 suppliers $20.00-$1480.00
C8 CERAMIDE-1-PHOSPHATE 158983-53-0 C26H52NO6P 24 suppliers $93.00-$1089.00
C8 Ceramide-1-phosphate 887353-95-9 C26H52NO6P 8 suppliers Inquiry

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