一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell reports >>article
Cell reports

Cell reports

IF: 7.5
Download PDF

The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.

Published:23 August 2022 DOI: 10.1016/j.celrep.2022.111210 PMID: 36001969
Tianzhuo Wang, Huiying Guo, Qianchen Li, Weijie Wu, Miao Yu, Lei Zhang, Cuicui Li, Jiagui Song, Zhenbin Wang, Jing Zhang, Yan Tang, Lei Kang, Hongquan Zhang, Jun Zhan

Abstract

HOXB9 is an important transcription factor associated with unfavorable outcomes in patients with lung adenocarcinoma (LUAD). However, its degradation mechanism remains unclear. Here, we show that HOXB9 is a substrate of AMP kinase alpha (AMPKα). AMPK mediates HOXB9 T133 phosphorylation and downregulates the level of HOXB9 in mice and LUAD cells. Mechanistically, phosphorylated HOXB9 promoted E3 ligase Praja2-mediated HOXB9 degradation. Blocking HOXB9 phosphorylation by depleting AMPKα1/2 or employing the HOXB9 T133A mutant promoted tumor cell growth in cell culture and mouse xenografts via upregulation of HOXB9 and KRAS that is herein identified as a target of HOXB9. Clinically, AMPK activation levels in LUAD samples were positively correlated with pHOXB9 levels; higher pHOXB9 levels were associated with better survival of patients with LUAD. We thus present a HOXB9 degradation mechanism and demonstrate an AMPK-HOXB9-KRAS axis linking glucose-level-regulated AMPK activation to HOXB9 stability and KRAS gene expression, ultimately controlling LUAD progression.

Substances (6)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide 1093222-27-5 C20H13N5O 75 suppliers Inquiry
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide 1093222-27-5 C20H13N5O 75 suppliers Inquiry
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide 1093222-27-5 C20H13N5O 75 suppliers Inquiry
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide 1093222-27-5 C20H13N5O 75 suppliers Inquiry

Similar articles

IF:3

The comparative gastrointestinal response of young children to the ingestion of 25 g sweets containing sucrose or isomalt

British Journal of Nutrition D. Storey,?Adam Lee,etc Published: 1 April 2002
IF:3.5

Conformational switches that control the TEC kinase – PLCγ signaling axis

Journal of Structural Biology: X Jacques Lowe, Raji E. Joseph,etc Published: 1 January 2022
IF:3.8

Oxaliplatin in perioperative chemotherapy for gastric and gastroesophageal junction (GEJ) adenocarcinoma.

Expert Review of Gastroenterology & Hepatology Ralph Fritsch, Jens Hoeppner,etc Published: 1 April 2019
紫金县| 陕西省| 邢台市| 香港 | 山东| 云林县| 株洲县| 赞皇县| 肥城市| 内江市| 石家庄市| 银川市| 汽车| 庆安县| 镇赉县| 海宁市| 子长县| 哈巴河县| 博兴县| 浦东新区| 霞浦县| 建宁县| 江陵县| 虎林市| 洮南市| 石屏县| 会东县| 洞口县| 育儿| 嘉荫县| 昌吉市| 雅安市| 和平县| 民和| 广德县| 闽侯县| 那坡县| 巴马| 济阳县| 河东区| 常州市|