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Molecular immunology

Molecular immunology

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IPO7 promotes lipopolysaccharide-induced inflammatory responses in human dental pulp cells via p38 MAPK and NF-κB signaling pathways

Published:26 September 2023 DOI: PMID: 37769576
Ziqiu Xiao, Yue Zhang, Yawei She, Guohua Yuan, Guobin Yang

Abstract

Pulpitis is a chronic inflammatory process that greatly affects the physical, mental health and life quality of patients. Human dental pulp cells (hDPCs) are essential components of dental pulp tissue and play a significant role in pulpitis. Lipopolysaccharide (LPS) is an initiator of pulpitis and can induce the production of inflammatory cytokines in hDPCs by activating p38 MAPK and NF-κB signaling pathways. Importin7 (IPO7), a member of the importin-β family, is widely expressed in many tissues. Previous studies have shown that IPO7 mediated nuclear translocation of p-p38 after stimulation, and IPO7 homologous protein IPO8 participated in human dental pulp inflammation. This research aims to investigate whether IPO7 is involved in pulpitis and explore its underlying mechanisms. In the current study, we found the expression of IPO7 was increased in pulpitis tissue. In vitro, hDPCs treated with LPS to mimic the inflammatory environment, the expression of IPO7 was increased. Knockdown of IPO7 significantly inhibited the production of inflammatory cytokines and suppressed the p38 MAPK and NF-κB signaling pathways. Activating the p38 MAPK and NF-κB signaling pathways by the p38 activator and p65 activator reversed the inflammatory responses. IPO7 interacted with p-p38 under LPS stimulation in hDPCs. In addition, the increased binding between IPO7 and p-p38 is associated with the decreased binding ability of IPO7 to Sirt2. In conclusion, we found that IPO7 was highly expressed in pulpitis and played a vital role in modulating human dental pulp inflammation.

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Asiatic acid 464-92-6 C30H48O5 445 suppliers $25.00-$2484.00
Asiatic acid 464-92-6 C30H48O5 445 suppliers $25.00-$2484.00
Asiatic acid 464-92-6 C30H48O5 445 suppliers $25.00-$2484.00
Asiatic acid 464-92-6 C30H48O5 445 suppliers $25.00-$2484.00
Asiatic acid 464-92-6 - Inquiry
Asiatic acid 464-92-6 - Inquiry

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