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ACS Omega

ACS Omega

IF: 3.7
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Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora

Published:28 September 2023 DOI: 10.1021/acsomega.3c03055
Meng-Ying Li, Jia-Qi Duan, Xiao-Hui Wang, Meng Liu, Qiao-Yi Yang, Yan Li, Kun Cheng, Han-Qiang Liu* and Feng Wang*, 

Abstract

Inulin, a commonly used dietary fiber supplement, is capable of modulating the gut microbiome. Chronic inflammation resulting from metabolic abnormalities and gut flora dysfunction plays a significant role in the development of type 2 diabetes mellitus (T2DM). Our research has demonstrated that inulin administration effectively reduced colonic inflammation in T2DM mice by inducing changes in the gut microbiota and increasing the concentration of butyric acid, which in turn modulated the function of enteric glial cells (EGCs). Experiments conducted on T2DM mice revealed that inulin administration led to an increase in the Bacteroidetes/Firmicutes ratio and the concentration of butyric acid in the colon. The anti-inflammatory effects of altered gastrointestinal flora and its metabolites were further confirmed through fecal microbiota transplantation. Butyric acid was found to inhibit the activation of the κB inhibitor kinase β/nuclear factor κB pathway, regulate the expression levels of interleukin-6 and tumor necrosis factor-α, suppress the abnormal activation of EGCs, and prevent the release of inflammatory factors by EGCs. Similar results were observed in vitro experiments with butyric acid. Our findings demonstrate that inulin, by influencing the intestinal flora, modifies the activity of EGCs to effectively reduce colonic inflammation in T2DM mice.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
MPMKMQHJHDHPBE-RUZDIDTESA-N 1391076-61-1 C25H25ClN2O4S 41 suppliers $61.00-$3570.00
MPMKMQHJHDHPBE-RUZDIDTESA-N 1391076-61-1 C25H25ClN2O4S 41 suppliers $61.00-$3570.00
MPMKMQHJHDHPBE-RUZDIDTESA-N 1391076-61-1 C25H25ClN2O4S 41 suppliers $61.00-$3570.00
MPMKMQHJHDHPBE-RUZDIDTESA-N 1391076-61-1 C25H25ClN2O4S 41 suppliers $61.00-$3570.00

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