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Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet

Published:22 August 2019 DOI: 10.3390/molecules24173051 PMID: 31443447
Seon-A Jang, Youn-Hwan Hwang, Taesoo Kim, Ami Lee, Hyunil Ha

Abstract

In traditional oriental medicine, Drynaria roosii Nakaike is widely used in treating bone diseases. Postmenopausal women are strongly associated with osteoporosis and obesity. This study aimed to investigate the effects of the water extract of D. roosii (WDR) on bone loss and obesity in ovariectomized (OVX) mice fed a high-fat diet (HFD). Body weight, gonadal fat weight, histological findings, and morphometric parameters in trabecular bone were evaluated after OVX mice were treated with WDR and HFD for four weeks. The receptor activator of nuclear κ-B ligand (RANKL)-induced osteoclast differentiation in bone marrow-derived macrophages (BMMs) was examined. Phytochemical identification of WDR using ultrahigh-performance liquid chromatography-tandem mass spectrometry was performed. WDR reversed the changes in body weight gain, gonadal fat mass, and trabecular bone parameters by ovariectomy. However, ovariectomy-induced uterine atrophy was not affected by WDR. WDR decreased adipocyte size and pro-inflammatory cytokines (interleukin (IL)-1β and IL-6) in gonadal fats and lipid accumulation in the bone marrow, which were induced by ovariectomy. WDR significantly decreased RANKL-induced osteoclast differentiation in BMMs. Fifteen phytochemicals were identified in WDR: Seven and nine with anti-osteoporotic and anti-adipogenic activities, respectively. Our findings suggest that WDR may have beneficial effects on postmenopausal osteoporosis and obesity.

Substances (98)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Protocatechuic acid 99-50-3 C7H6O4 802 suppliers $6.00-$1550.00
Protocatechuic acid 99-50-3 C7H6O4 802 suppliers $6.00-$1550.00

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