一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Molecules >>article
Molecules

Molecules

IF: 4.2
Download PDF

Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet

Published:22 August 2019 DOI: 10.3390/molecules24173051 PMID: 31443447
Seon-A Jang, Youn-Hwan Hwang, Taesoo Kim, Ami Lee, Hyunil Ha

Abstract

In traditional oriental medicine, Drynaria roosii Nakaike is widely used in treating bone diseases. Postmenopausal women are strongly associated with osteoporosis and obesity. This study aimed to investigate the effects of the water extract of D. roosii (WDR) on bone loss and obesity in ovariectomized (OVX) mice fed a high-fat diet (HFD). Body weight, gonadal fat weight, histological findings, and morphometric parameters in trabecular bone were evaluated after OVX mice were treated with WDR and HFD for four weeks. The receptor activator of nuclear κ-B ligand (RANKL)-induced osteoclast differentiation in bone marrow-derived macrophages (BMMs) was examined. Phytochemical identification of WDR using ultrahigh-performance liquid chromatography-tandem mass spectrometry was performed. WDR reversed the changes in body weight gain, gonadal fat mass, and trabecular bone parameters by ovariectomy. However, ovariectomy-induced uterine atrophy was not affected by WDR. WDR decreased adipocyte size and pro-inflammatory cytokines (interleukin (IL)-1β and IL-6) in gonadal fats and lipid accumulation in the bone marrow, which were induced by ovariectomy. WDR significantly decreased RANKL-induced osteoclast differentiation in BMMs. Fifteen phytochemicals were identified in WDR: Seven and nine with anti-osteoporotic and anti-adipogenic activities, respectively. Our findings suggest that WDR may have beneficial effects on postmenopausal osteoporosis and obesity.

Substances (98)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
4-Hydroxybenzoic acid 99-96-7 C7H6O3 997 suppliers $5.00-$2460.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Chlorogenic acid 327-97-9 C16H18O9 885 suppliers $5.00-$1295.00
Protocatechuic acid 99-50-3 C7H6O4 802 suppliers $6.00-$1550.00
Protocatechuic acid 99-50-3 C7H6O4 802 suppliers $6.00-$1550.00

Similar articles

IF:5.3

iPSCs‐derived iMSCs prevent osteoporotic bone loss and affect bone metabolites in ovariectomized mice

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Wei‐Zhou Wang, Yang‐Hao Wang,etc Published: 24 November 2024
IF:5.6

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

International Journal of Molecular Sciences Elena A Tukhovskaya, Elvira R Shaykhutdinova,etc Published: 11 December 2022
和龙市| 洞口县| 潞城市| 阿坝县| 佛学| 逊克县| 新巴尔虎左旗| 固安县| 体育| 长葛市| 鹰潭市| 肃北| 湘潭县| 本溪| 铅山县| 科技| 江源县| 吉首市| 达日县| 汪清县| 福泉市| 昭苏县| 枣强县| 苏尼特左旗| 九龙县| 苍溪县| 上思县| 浪卡子县| 嘉荫县| 遂平县| 平南县| 徐州市| 吉林省| 鄯善县| 剑河县| 韶关市| 元氏县| 富川| 甘谷县| 曲阜市| 太谷县|