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Viruses-Basel

Viruses-Basel

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Montelukast Inhibits HCoV-OC43 Infection as a Viral Inactivator

Published:21 April 2022 DOI: 10.3390/v14050861
Yongkang Chen,?Xiaohuan Wang,?Huichun Shi,?Peng Zou

Abstract

Coronaviruses (CoVs) consist of a large group of RNA viruses causing various diseases in humans and in lots of animals. Human coronavirus (HCoV) OC43, the prototype of beta-coronavirus discovered in the 1960s, has been circulating in humans for long time, and infection with other emerging strains of beta-coronavirus (SARS-CoV, SARS-CoV-2, and MERS-CoV) can lead to severe illness and death. In this study, we found that montelukast, a leukotriene receptor antagonist, potently inhibited the infection of HCoV-OC43 in distinct cells in a dose- and time- dependent manner. Additionally, the results showed that montelukast induced release of HCoV-OC43 genomic RNA by disrupting the integrity of the viral lipid membrane, and irreversibly inhibited viral infection. Considering the similarity among HCoV-OC43, MERS-CoV, and SARS-CoV-2, it suggests that montelukast may be a potential candidate for the treatment of human beta-coronavirus infection.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
DIGITONIN 11024-24-1 C56H92O29 373 suppliers $32.00-$3000.00
DIGITONIN 11024-24-1 C56H92O29 373 suppliers $32.00-$3000.00
DIGITONIN 11024-24-1 C56H92O29 373 suppliers $32.00-$3000.00
DIGITONIN 11024-24-1 C56H92O29 373 suppliers $32.00-$3000.00

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