一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation

Published:14 September 2022 DOI: 10.1002/advs.202203995 PMID: 36106364
Han Liu, Yuefeng Liu, He Wang, Qiang Zhao, Tao Zhang, Si-an Xie, Yueqi Liu, Yuanjun Tang, Qin Peng, Wei Pang, Weijuan Yao, Jing Zhou

Abstract

Vascular smooth muscle cells (SMCs) can adapt to changes in cellular geometric cues; however, the underlying mechanisms remain elusive. Using 2D micropatterned substrates to engineer cell geometry, it is found that in comparison with an elongated geometry, a square-shaped geometry causes the nuclear-to-cytoplasmic redistribution of DNA methyltransferase 1 (DNMT1), hypermethylation of mitochondrial DNA (mtDNA), repression of mtDNA gene transcription, and impairment of mitochondrial function. Using irregularly arranged versus circumferentially aligned vascular grafts to control cell geometry in 3D growth, it is demonstrated that cell geometry, mtDNA methylation, and vessel contractility are closely related. DNMT1 redistribution is found to be dependent on the phosphoinositide 3-kinase and protein kinase B (AKT) signaling pathways. Cell elongation activates cytosolic phospholipase A2, a nuclear mechanosensor that, when inhibited, hinders AKT phosphorylation, DNMT1 nuclear accumulation, and energy production. The findings of this study provide insights into the effects of cell geometry on SMC function and its potential implications in the optimization of vascular grafts.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
LY 294002 Hydrochloride 154447-36-6 C19H17NO3 405 suppliers $12.00-$3350.00
LY 294002 Hydrochloride 154447-36-6 C19H17NO3 405 suppliers $12.00-$3350.00
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol 937174-76-0 C21H27N7O3 197 suppliers $28.00-$4722.00
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol 937174-76-0 C21H27N7O3 197 suppliers $28.00-$4722.00

Similar articles

IF:14.3

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure

Advanced Science Xiuru Cui, Yawei Wang,etc Published: 26 November 2024
IF:5

Effect of magnesium chloride on rabbit bronchial smooth muscle.

Annals of emergency medicine W H Spivey, E M Skobeloff,etc Published: 1 October 1990
井陉县| 堆龙德庆县| 天峨县| 孟津县| 淮北市| 承德市| 汽车| 唐海县| 天水市| 南宫市| 西贡区| 德江县| 会昌县| 盐山县| 老河口市| 东平县| 榆树市| 阳城县| 衡山县| 轮台县| 闽清县| 吉首市| 崇左市| 吴忠市| 温州市| 泌阳县| 延长县| 保定市| 云浮市| 嘉兴市| 石狮市| 青岛市| 邮箱| 博客| 定边县| 灵川县| 丹江口市| 尉氏县| 枣庄市| 长子县| 洪江市|