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Resveratrol, a New Allosteric Effector of Hemoglobin, Enhances Oxygen Supply Efficiency and Improves Adaption to Acute Severe Hypoxia

Published:22 February 2023 DOI: 10.3390/molecules28052050 PMID: 36903296
Zongtang Chu, Weidan Li, Guoxing You, Yuzhi Chen, Dong Qin, Peilin Shu, Yujing Wang, Ying Wang, Lian Zhao, Hong Zhou

Abstract

Acute altitude hypoxia represents the cause of multiple adverse consequences. Current treatments are limited by side effects. Recent studies have shown the protective effects of resveratrol (RSV), but the mechanism remains unknown. To address this, the effects of RSV on the structure and function of hemoglobin of adult (HbA) were preliminarily analyzed using surface plasmon resonance (SPR) and oxygen dissociation assays (ODA). Molecular docking was conducted to specifically analyze the binding regions between RSV and HbA. The thermal stability was characterized to further validate the authenticity and effect of binding. Changes in the oxygen supply efficiency of HbA and rat RBCs incubated with RSV were detected ex vivo. The effect of RSV on the anti-hypoxic capacity under acute hypoxic conditions in vivo was evaluated. We found that RSV binds to the heme region of HbA following a concentration gradient and affects the structural stability and rate of oxygen release of HbA. RSV enhances the oxygen supply efficiency of HbA and rat RBCs ex vivo. RSV prolongs the tolerance times of mice suffering from acute asphyxia. By enhancing the oxygen supply efficiency, it alleviates the detrimental effects of acute severe hypoxia. In conclusion, RSV binds to HbA and regulates its conformation, which enhances oxygen supply efficiency and improves adaption to acute severe hypoxia.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 - Inquiry
Resveratrol 501-36-0 - Inquiry
Resveratrol 98% 501-36-0 C14H12O3 - Inquiry
Resveratrol 98% 501-36-0 C14H12O3 - Inquiry
Resveratrol 501-36-0 - Inquiry
Resveratrol 501-36-0 - Inquiry

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