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Biological Trace Element Research

Biological Trace Element Research

IF: 3.4
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Involvement of TRPM2 Channel on Doxorubicin-Induced Experimental Cardiotoxicity Model: Protective Role of Selenium

Published:1 May 2023 DOI: 10.1007/s12011-022-03377-2 PMID: 35922740
Kenan Y?ld?zhan, Zübeyir Huyut, Fikret Alt?nda?

Abstract

Doxorubicin (DOXR) is an important chemotherapeutic drug used in cancer treatment for many years. Several studies reported that the use of DOXR increased toxicity by causing an increase in oxidative stress (OS), especially in the heart. In this study, we investigated the protective effect of selenium (Se) and the role of transient receptor potential melastatin-2 (TRPM2) channel activation by using N-(p-amylcinnamoyl) anthranilic acid (ACA) in a model of DOXR-induced cardiotoxicity. Sixty female rats were equally divided into the control, dimethyl sulfoxide (DMSO), DOXR, DOXR?+?Se, DOXR?+?ACA, and DOXR?+?Se?+?ACA groups. Glutathione (GSH), glutathione peroxidase (GSH-Px), caspases (Cas) 3 and 9, interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), reactive oxygen species (ROS), poly [ADP-ribose] polymerase 1 (PARP-1), and TRPM2 channel levels were measured by ELISA. In addition, histopathological examination was performed in cardiac tissues and TNF-α, caspase 3, and TRPM2 channel expression levels were determined immunohistochemically. The levels of GSH, GSH-Px, caspases 3 and 9, IL-1β, TNF-α, ROS, PARP-1, and TRPM2 channel in serum, and cardiac tissue in the DOXR group were higher than in the control and DMSO groups (p?

Substances (14)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
ACA 110683-10-8 C21H23NO3 79 suppliers $47.00-$3160.00
ACA 110683-10-8 C21H23NO3 79 suppliers $47.00-$3160.00
ACA 110683-10-8 C21H23NO3 79 suppliers $47.00-$3160.00
ACA 110683-10-8 C21H23NO3 79 suppliers $47.00-$3160.00
Doxorubicin hydrochloride 25316-40-9 - Inquiry
Doxorubicin hydrochloride 25316-40-9 - Inquiry

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