一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell Death & Disease >>article
Cell Death & Disease

Cell Death & Disease

IF: 8.1
Download PDF

Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell

Published:20 February 2023 DOI: 10.1038/s41419-023-05611-8 PMID: 36805688
Xincheng Liu, Cui Guo, Tiandong Leng, Zhen Fan, Jialuo Mai, Jiehong Chen, Jinhai Xu, Qianyi Li, Bin Jiang, Ke Sai, Wenzhuo Yang, Jiayu Gu, Jingyi Wang, Shuxin Sun, Zhijie Chen, Yingqian Zhong, Xuanming Liang, Chaoxin Chen, Jing Cai, Yuan Lin, Jiankai Liang, Jun Hu, Guangmei Yan, Wenbo Zhu, Wei Yin

Abstract

Differentiation therapy using small molecules is a promising strategy for improving the prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate determination. Nevertheless, whether histone acetylation in specific sites determines GBM cells fate remains to be explored. Through screening from a 349 small molecule-library, we identified that histone deacetylase inhibitor (HDACi) MS-275 synergized with 8-CPT-cAMP was able to transdifferentiate U87MG GBM cells into neuron-like cells, which were characterized by cell cycle arrest, rich neuron biomarkers, and typical neuron electrophysiology. Intriguingly, acetylation tags of histone 3 at lysine 9 (H3K9ac) were decreased in the promoter of multiple oncogenes and cell cycle genes, while ones of H3K9ac and histone 3 at lysine 14 (H3K14ac) were increased in the promoter of neuron-specific genes. We then compiled a list of genes controlled by H3K9ac and H3K14ac, and proved that it is a good predictive power for pathologic grading and survival prediction. Moreover, cAMP agonist combined with HDACi also induced glioma stem cells (GSCs) to differentiate into neuron-like cells through the regulation of H3K9ac/K14ac, indicating that combined induction has the potential for recurrence-preventive application. Furthermore, the combination of cAMP activator plus HDACi significantly repressed the tumor growth in a subcutaneous GSC-derived tumor model, and temozolomide cooperated with the differentiation-inducing combination to prolong the survival in an orthotopic GSC-derived tumor model. These findings highlight epigenetic reprogramming through H3K9ac and H3K14ac as a novel approach for driving neuron-fate-induction of GBM cells.

Substances (7)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Temozolomide 85622-93-1 C6H6N6O2 701 suppliers $5.00-$2935.00
Temozolomide 85622-93-1 C6H6N6O2 701 suppliers $5.00-$2935.00
Temozolomide 85622-93-1 C6H6N6O2 701 suppliers $5.00-$2935.00
Temozolomide 85622-93-1 C6H6N6O2 701 suppliers $5.00-$2935.00
85622-93-1 85622-93-1 C6H6N6O2 1 suppliers Inquiry
85622-93-1 85622-93-1 C6H6N6O2 1 suppliers Inquiry

Similar articles

IF:7.7

Critical roles of small silk fibroin molecules in the self-assembly and properties of regenerated silk fibroin

International Journal of Biological Macromolecules Hao Li, Yuanyuan Guo,etc Published: 21 November 2024
IF:5.3

Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer.

ACS Applied Nano Materials Jennifer Ferris, Margarita Espona-Fiedler,etc Published: 21 July 2020
夹江县| 永川市| 乌拉特前旗| 都兰县| 公主岭市| 南通市| 鹤山市| 沈丘县| 广饶县| 沽源县| 南城县| 临潭县| 海阳市| 弥勒县| 漠河县| 峨眉山市| 故城县| 九台市| 昌吉市| 潢川县| 闽侯县| 新津县| 武山县| 望谟县| 镇雄县| 湟源县| 嘉义县| 石屏县| 格尔木市| 滦平县| 安国市| 通辽市| 连山| 宜君县| 加查县| 项城市| 竹山县| 嘉善县| 朔州市| 宁南县| 托里县|