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Frontiers in Physiology

Frontiers in Physiology

IF: 3.2
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Role of MOTS-c in the regulation of bone metabolism.

Published:1 January 2023 DOI: 10.3389/fphys.2023.1149120 PMID: 37200834
Xuejie Yi, Guangxuan Hu, Yang Yang, Jing Li, Junjie Jin, Bo Chang

Abstract

MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism and is involved in the development of specific diseases. Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthermore, it inhibits osteoclast production and mediates the regulation of bone metabolism and bone remodeling. Exercise effectively upregulates the expression of MOTS-c, but the specific mechanism of MOTS-c regulation in bone by exercise remains unclear. Therefore, this article reviewed the distribution and function of MOTS-c in the tissue, discussed the latest research developments in the regulation of osteoblasts and osteoclasts, and proposed potential molecular mechanisms for the effect of exercise on the regulation of bone metabolism. This review provides a theoretical reference for establishing methods to prevent and treat skeletal metabolic diseases.

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MOTS-c 1627580-64-6 C101H152N28O22S2 152 suppliers Inquiry

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