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Cell Death & Disease
Cell Death & Disease
IF:8.1
CiteScore:15.1
Articles:935
Brought to readers by the editorial team of Cell Death & Differentiation, Cell Death & Disease is an online peer-reviewed journal specializing in translational cell death research. It covers a wide range of topics in experimental and internal medicine, including cancer, immunity, neuroscience, and now cancer metabolism.
Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following:
Experimental medicine
Cancer
Immunity
Internal medicine
Neuroscience
Cancer metabolism
Role of the androgen receptor in melanoma aggressiveness
Published: 21 January 2025
DOI: 10.1038/s41419-025-07350-4
Marzia Di Donato,?Costanza Maria Cristiani,?Mariaelena Capone,?Cinzia Garofalo,?Gabriele Madonna,?Lucia Carmela Passacatini,?Margaret Ottaviano,?Paolo Antonio Ascierto,?Ferdinando Auricchio,?Ennio Carbone,?Antimo Migliaccio,?Gabriella Castoria
Marzia Di Donato,?Costanza Maria Cristiani,?Mariaelena Capone,?Cinzia Garofalo,?Gabriele Madonna,?Lucia Carmela Passacatini,?Margaret Ottaviano,?Paolo Antonio Ascierto,?Ferdinando Auricchio,?Ennio Carbone,?Antimo Migliaccio,?Gabriella Castoria
The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease
Published: 14 January 2025
DOI: 10.1038/s41419-024-07328-8
Xudong Sha,?Jiayuan Lin,?Kexin Wu,?Jia Lu,?Zhihua Yu
Xudong Sha,?Jiayuan Lin,?Kexin Wu,?Jia Lu,?Zhihua Yu
Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner
Published: 4 January 2025
DOI: 10.1038/s41419-024-07322-0
Wen Ge,?Xiaohua Zhang,?Jie Lin,?Yangyang Wang,?Xiao Zhang,?Yu Duan,?Xinchun Dai,?Jiye Zhang,?Yan Zhang,?Mengyuan Jiang,?Huanhuan Qiang,?Zhijing Zhao,?Xuebin Zhang,?Dongdong Sun
Wen Ge,?Xiaohua Zhang,?Jie Lin,?Yangyang Wang,?Xiao Zhang,?Yu Duan,?Xinchun Dai,?Jiye Zhang,?Yan Zhang,?Mengyuan Jiang,?Huanhuan Qiang,?Zhijing Zhao,?Xuebin Zhang,?Dongdong Sun
Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics
Published: 22 November 2024
DOI: 10.1038/s41419-024-07253-w
Wang, Yuhan, Liu, Zijian, Si, Qian, Lu, Wanqiu, Song, Yuxian, Jin, Wanyong, Yang, Xihu, Li, Zihui, Hu, Xinyang, Ding, Liang, Jing, Yue, Weng, Pei, Yu, Qiuya, O’Reilly, Lorraine A., Silke, John, Zhang, Xiaoxin, Hu, Qingang, Ni, Yanhong
Wang, Yuhan, Liu, Zijian, Si, Qian, Lu, Wanqiu, Song, Yuxian, Jin, Wanyong, Yang, Xihu, Li, Zihui, Hu, Xinyang, Ding, Liang, Jing, Yue, Weng, Pei, Yu, Qiuya, O’Reilly, Lorraine A., Silke, John, Zhang, Xiaoxin, Hu, Qingang, Ni, Yanhong
Seratrodast inhibits ferroptosis by suppressing lipid peroxidation.
Published: 22 November 2024
DOI: 10.1038/s41419-024-07251-y
Juliane Tschuck,?Wulf Tonnus,?Shubhangi Gavali,?Andrea Kolak,?Melodie Mallais,?Francesca Maremonti,?Mami Sato,?Ina Rothenaigner,?José Pedro Friedmann Angeli,?Derek A Pratt,?Andreas Linkermann,?Kamyar Hadian
Juliane Tschuck,?Wulf Tonnus,?Shubhangi Gavali,?Andrea Kolak,?Melodie Mallais,?Francesca Maremonti,?Mami Sato,?Ina Rothenaigner,?José Pedro Friedmann Angeli,?Derek A Pratt,?Andreas Linkermann,?Kamyar Hadian
SNF2L maintains glutathione homeostasis by initiating SLC7A11 transcription through chromatin remodeling
Published: 12 November 2024
DOI: 10.1038/s41419-024-07221-4
Jiaguan Zhang,?Zeshou Gao,?Yi Yang,?Zhenhao Li,?Binjie Wu,?Chunxin Fan,?Yuyan Zheng,?Ruohan Yang,?Fangrong Zhang,?Xiaohuang Lin,?Daoshan Zheng
Jiaguan Zhang,?Zeshou Gao,?Yi Yang,?Zhenhao Li,?Binjie Wu,?Chunxin Fan,?Yuyan Zheng,?Ruohan Yang,?Fangrong Zhang,?Xiaohuang Lin,?Daoshan Zheng
VASH2 enhances KIF3C-mediated EGFR-endosomal recycling to promote aggression and chemoresistance of lung squamous cell carcinoma by increasing tubulin detyrosination
Published: 23 October 2024
DOI: 10.1038/s41419-024-07155-x
Jing Wang,?Pengpeng Liu,?Rui Zhang,?Biyuan Xing,?Guidong Chen,?Lei Han,?Jinpu Yu
Jing Wang,?Pengpeng Liu,?Rui Zhang,?Biyuan Xing,?Guidong Chen,?Lei Han,?Jinpu Yu
The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment
Published: 18 October 2024
DOI: 10.1038/s41419-024-07145-z
Maoxiao Feng,?Qinlian Jiao,?Yidan Ren,?Xiaoyan Liu,?Zihan Gao,?Zhengjun Li,?Yunshan Wang,?Miaoqing Zhao,?Lei Bi
Maoxiao Feng,?Qinlian Jiao,?Yidan Ren,?Xiaoyan Liu,?Zihan Gao,?Zhengjun Li,?Yunshan Wang,?Miaoqing Zhao,?Lei Bi
USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression
Published: 15 October 2024
DOI: 10.1038/s41419-024-07136-0
Rongfu Tu,?Junpeng Ma,?Yule Chen,?Ye Kang,?Doudou Ren,?Zeqiong Cai,?Ru Zhang,?Yiwen Pan,?Yijia Liu,?Yanyan Da,?Yao Xu,?Yahuan Yu,?Donghai Wang,?Jingchao Wang,?Yang Dong,?Xinlan Lu,?Chengsheng Zhang
Rongfu Tu,?Junpeng Ma,?Yule Chen,?Ye Kang,?Doudou Ren,?Zeqiong Cai,?Ru Zhang,?Yiwen Pan,?Yijia Liu,?Yanyan Da,?Yao Xu,?Yahuan Yu,?Donghai Wang,?Jingchao Wang,?Yang Dong,?Xinlan Lu,?Chengsheng Zhang
ACSL4-mediated lipid rafts prevent membrane rupture and inhibit immunogenic cell death in melanoma
Published: 29 September 2024
DOI: 10.1038/s41419-024-07098-3
Xi Zhao,?Zenglu Zhao,?Bingru Li,?Shuyu Huan,?Zixi Li,?Jianlan Xie,?Guoquan Liu
Xi Zhao,?Zenglu Zhao,?Bingru Li,?Shuyu Huan,?Zixi Li,?Jianlan Xie,?Guoquan Liu
Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway
Published: 11 September 2024
DOI: 10.1038/s41419-024-07007-8
Guoqing Xie, Ningyang Li, Keqiang Li, Yating Xu, Yu Zhang, Shun Cao, Budeng Huang, Ruoyang Liu, Peijie Zhou, Yafei Ding, Yinghui Ding, Jinjian Yang, Zhankui Jia, Zhenlin Huang
Guoqing Xie, Ningyang Li, Keqiang Li, Yating Xu, Yu Zhang, Shun Cao, Budeng Huang, Ruoyang Liu, Peijie Zhou, Yafei Ding, Yinghui Ding, Jinjian Yang, Zhankui Jia, Zhenlin Huang
Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification
Published: 13 August 2024
DOI: 10.1038/s41419-024-06985-z
Yunye Liu,?Yawen Guo,?Qian Zeng,?Yiqun Hu,?Ru He,?Wenli Ma,?Chenhong Qian,?Tebo Hua,?Fahuan Song,?Yefeng Cai,?Lei Zhu,?Xinxin Ren,?Jiajie Xu,?Chuanming Zheng,?Lingling Ding,?Jingyan Ge,?Wenzhen Wang,?Haifeng Xu,?Minghua Ge,?Guowan Zheng
Yunye Liu,?Yawen Guo,?Qian Zeng,?Yiqun Hu,?Ru He,?Wenli Ma,?Chenhong Qian,?Tebo Hua,?Fahuan Song,?Yefeng Cai,?Lei Zhu,?Xinxin Ren,?Jiajie Xu,?Chuanming Zheng,?Lingling Ding,?Jingyan Ge,?Wenzhen Wang,?Haifeng Xu,?Minghua Ge,?Guowan Zheng
Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1
Published: 3 August 2024
DOI: 10.1038/s41419-024-06941-x
Ying Sui,?Ziyang Shen,?Xiaoyou Li,?Ya Lu,?SiTong Feng,?Rong Ma,?Jianzhong Wu,?Changwen Jing,?Zhuo Wang,?Jifeng Feng,?Haixia Cao
Ying Sui,?Ziyang Shen,?Xiaoyou Li,?Ya Lu,?SiTong Feng,?Rong Ma,?Jianzhong Wu,?Changwen Jing,?Zhuo Wang,?Jifeng Feng,?Haixia Cao
Onvansertib treatment overcomes olaparib resistance in high-grade ovarian carcinomas
Published: 22 July 2024
DOI: 10.1038/s41419-024-06894-1
Michela Chiappa,?Alessandra Decio,?Luca Guarrera,?Ilaria Mengoli,?Anju Karki,?Divora Yemane,?Carmen Ghilardi,?Eugenio Scanziani,?Simone Canesi,?Maria C Barbera,?Ilaria Craparotta,?Marco Bolis,?Robert Fruscio,?Chiara Grasselli,?Tommaso Ceruti,?Massimo Zucchetti,?Jesse C Patterson,?Robin A Lu,?Micheal B Yaffe,?Maya Ridinger,?Giovanna Damia,?Federica Guffanti
Michela Chiappa,?Alessandra Decio,?Luca Guarrera,?Ilaria Mengoli,?Anju Karki,?Divora Yemane,?Carmen Ghilardi,?Eugenio Scanziani,?Simone Canesi,?Maria C Barbera,?Ilaria Craparotta,?Marco Bolis,?Robert Fruscio,?Chiara Grasselli,?Tommaso Ceruti,?Massimo Zucchetti,?Jesse C Patterson,?Robin A Lu,?Micheal B Yaffe,?Maya Ridinger,?Giovanna Damia,?Federica Guffanti
SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis
Published: 10 July 2024
DOI: 10.1038/s41419-024-06882-5
Huimou Chen,?Jing Hu,?Xilin Xiong,?Hongling Chen,?Qiaofang Liao,?Biaojun Lin,?Yusong Chen,?Yanting Peng,?Yang Li,?Di Cheng,?Zhihua Li
Huimou Chen,?Jing Hu,?Xilin Xiong,?Hongling Chen,?Qiaofang Liao,?Biaojun Lin,?Yusong Chen,?Yanting Peng,?Yang Li,?Di Cheng,?Zhihua Li
Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages
Published: 6 June 2024
DOI: 10.1038/s41419-024-06785-5
Changjian Zhu,?Ruilin Zheng,?Xu Han,?Ziwen Tang,?Feng Li,?Xinrong Hu,?Ruoni Lin,?Jiani Shen,?Qiaoqiao Pei,?Rong Wang,?Guangyan Wei,?Zhenwei Peng,?Wei Chen,?Zhou Liang,?Yi Zhou
Changjian Zhu,?Ruilin Zheng,?Xu Han,?Ziwen Tang,?Feng Li,?Xinrong Hu,?Ruoni Lin,?Jiani Shen,?Qiaoqiao Pei,?Rong Wang,?Guangyan Wei,?Zhenwei Peng,?Wei Chen,?Zhou Liang,?Yi Zhou
Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis)
Published: 29 May 2024
DOI: 10.1038/s41419-024-06751-1
Zihuan Wang,?Xu Zhang,?Yuchen Luo,?Yijiang Song,?Cheng Xiang,?Yilin He,?Kejin Wang,?Yingnan Yu,?Zhen Wang,?Wenxuan Peng,?Yi Ding,?Side Liu,?Changjie Wu
Zihuan Wang,?Xu Zhang,?Yuchen Luo,?Yijiang Song,?Cheng Xiang,?Yilin He,?Kejin Wang,?Yingnan Yu,?Zhen Wang,?Wenxuan Peng,?Yi Ding,?Side Liu,?Changjie Wu
Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo
Published: 14 March 2024
DOI: 10.1038/s41419-024-06597-7
Zhaohua Cai,?Shaojin You,?Zhixue Liu,?Ping Song,?Fujie Zhao,?Junqing An,?Ye Ding,?Ben He,?Ming-Hui Zou
Zhaohua Cai,?Shaojin You,?Zhixue Liu,?Ping Song,?Fujie Zhao,?Junqing An,?Ye Ding,?Ben He,?Ming-Hui Zou
Ruxolitinib induces apoptosis and pyroptosis of anaplastic thyroid cancer via the transcriptional inhibition of DRP1-mediated mitochondrial fission
Published: 9 February 2024
DOI: 10.1038/s41419-024-06511-1
Ya-Wen Guo,?Lei Zhu,?Yan-Ting Duan,?Yi-Qun Hu,?Le-Bao Li,?Wei-Jiao Fan,?Fa-Huan Song,?Ye-Feng Cai,?Yun-Ye Liu,?Guo-Wan Zheng,?Ming-Hua Ge
Ya-Wen Guo,?Lei Zhu,?Yan-Ting Duan,?Yi-Qun Hu,?Le-Bao Li,?Wei-Jiao Fan,?Fa-Huan Song,?Ye-Feng Cai,?Yun-Ye Liu,?Guo-Wan Zheng,?Ming-Hua Ge
Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL
Published: 8 February 2024
DOI: 10.1038/s41419-024-06514-y
Jingyi Li,?Xingfeng Liu,?Yuanyuan Liu,?Fangmin Huang,?Jiankun Liang,?Yingying Lin,?Fen Hu,?Jianting Feng,?Zeteng Han,?Yushi Chen,?Xuan Chen,?Qiaofa Lin,?Lanqin Wu,?Lisheng Li
Jingyi Li,?Xingfeng Liu,?Yuanyuan Liu,?Fangmin Huang,?Jiankun Liang,?Yingying Lin,?Fen Hu,?Jianting Feng,?Zeteng Han,?Yushi Chen,?Xuan Chen,?Qiaofa Lin,?Lanqin Wu,?Lisheng Li