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Frontiers in Immunology
Frontiers in Immunology
IF:5.7
CiteScore:9.8
Articles:7153
Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.
HIV subtype-specific gp140-CD4 binding, Temsavir efficacy, and identification of novel adhesion inhibitors against Chinese HIV strains
Published: 22 September 2025
DOI: 10.3389/fimmu.2025.1648546
Tianyang Liu,?Xiaowen Li,?Xiaolin Yang,?Shengjie Zhang,?Yao Wang,?Siwei Zhang,?Lin Cheng,?Shanshan Tang,?Fuxiang Wang,?Yao Zhao,?Hongzhou Lu,?Lanlan Wei
Tianyang Liu,?Xiaowen Li,?Xiaolin Yang,?Shengjie Zhang,?Yao Wang,?Siwei Zhang,?Lin Cheng,?Shanshan Tang,?Fuxiang Wang,?Yao Zhao,?Hongzhou Lu,?Lanlan Wei
PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome
Published: 11 September 2025
DOI: 10.3389/fimmu.2025.1610713
Hua Ma,?Dahe Qi,?Yating Xu,?Tingting Shang,?Yu Si,?Wenyue Chen,?Hongting Zhao,?Qingling Ren
Hua Ma,?Dahe Qi,?Yating Xu,?Tingting Shang,?Yu Si,?Wenyue Chen,?Hongting Zhao,?Qingling Ren
Arsenic sulfide enhances the therapeutic effect of hepatocellular carcinoma immunotherapy through STAT3-THBS1/CD47 pathway
Published: 11 September 2025
DOI: 10.3389/fimmu.2025.1612318
Ting Kang,?Zhuowei Feng,?Yu Cai,?Ruizhe Huang,?Ruiheng Wang,?Zhiyi Liu,?Shumin Lu,?Shufeng Xie,?Han Liu,?Siyu Chen
Ting Kang,?Zhuowei Feng,?Yu Cai,?Ruizhe Huang,?Ruiheng Wang,?Zhiyi Liu,?Shumin Lu,?Shufeng Xie,?Han Liu,?Siyu Chen
Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway
Published: 3 September 2025
DOI: 10.3389/fimmu.2025.1628970
Haoran Wang,?Zekai Zhu,?Jun Liu
Haoran Wang,?Zekai Zhu,?Jun Liu
The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression
Published: 1 September 2025
DOI: 10.3389/fimmu.2025.1612041
Qihang Yan,?Chendi Xu,?Li Gong,?Dachuan Liang,?Jie Yang,?Yuzhen Zheng,?Junye Wang
Qihang Yan,?Chendi Xu,?Li Gong,?Dachuan Liang,?Jie Yang,?Yuzhen Zheng,?Junye Wang
Pan-cancer analysis of TMED2: unraveling potential immune characteristics and prognostic value in cancer therapy
Published: 30 May 2025
DOI: 10.3389/fimmu.2025.1578627
Zhuangzhi Wang,?Changning Sun,?Pengfei Wang,?Shouyang Lin,?Xiao Wu,?Yuchao Gu
Zhuangzhi Wang,?Changning Sun,?Pengfei Wang,?Shouyang Lin,?Xiao Wu,?Yuchao Gu
Transcriptional profiling reveals H.pylori-associated genes induced inflammatory cell infiltration and chemoresistance in gastric cancer
Published: 30 May 2025
DOI: 10.3389/fimmu.2025.1592558
Jinshui Tan,?Zhengxin Wu,?Yuankun Liu,?Wei Wang,?Wenjuan Qin,?Guangchao Pan,?Yubo Xiong,?Jingsong Ma,?Jiabao Zhao,?Huiwen Zhou,?ZhengJin Liu,?Haijie Lu,?Huiqin Zhuo,?Xuehui Hong
Jinshui Tan,?Zhengxin Wu,?Yuankun Liu,?Wei Wang,?Wenjuan Qin,?Guangchao Pan,?Yubo Xiong,?Jingsong Ma,?Jiabao Zhao,?Huiwen Zhou,?ZhengJin Liu,?Haijie Lu,?Huiqin Zhuo,?Xuehui Hong
25-hydroxycholesterol: an integrator of antiviral ability and signaling.
Published: 13 September 2023
DOI: 10.3389/fimmu.2023.1268104
Jialu Zhang, Yaohong Zhu, Xiaojia Wang, Jiufeng Wang
Jialu Zhang, Yaohong Zhu, Xiaojia Wang, Jiufeng Wang
Mapping of DNA methylation-sensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis
Published: 26 January 2023
DOI: 10.3389/fimmu.2023.1078031
Katarzyna B Lagosz-Cwik,?Mariia Melnykova,?Elwira Nieboga,?Aureliusz Schuster,?Agnieszka Bysiek,?Slawomir Dudek,?Weronika Lipska,?Malgorzata Kantorowicz,?Michal Tyrakowski,?Dagmara Darczuk,?Tomasz Kaczmarzyk,?Marjolijn Gilijamse,?Teun J de Vries,?Jan Potempa,?Aleksander M Grabiec
Katarzyna B Lagosz-Cwik,?Mariia Melnykova,?Elwira Nieboga,?Aureliusz Schuster,?Agnieszka Bysiek,?Slawomir Dudek,?Weronika Lipska,?Malgorzata Kantorowicz,?Michal Tyrakowski,?Dagmara Darczuk,?Tomasz Kaczmarzyk,?Marjolijn Gilijamse,?Teun J de Vries,?Jan Potempa,?Aleksander M Grabiec
The transdermal cream of Formestane anti-breast cancer by controlling PI3K-Akt pathway and the tumor immune microenvironment.
Published: 1 January 2023
DOI: 10.3389/fimmu.2023.1041525
Lanyang Gao, Lei Zhu, Chen Shen, Xiaoming Hou, Youyou Chen, Linglin Zou, Huiyan Qiang, Alexander T Teichmann, Wenguang Fu, Yao Luo
Lanyang Gao, Lei Zhu, Chen Shen, Xiaoming Hou, Youyou Chen, Linglin Zou, Huiyan Qiang, Alexander T Teichmann, Wenguang Fu, Yao Luo
TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.
Published: 28 April 2022
DOI: 10.3389/fimmu.2022.883885
Bingqing Shi,?Yuqiu Hao,?Wei Li,?Hongna Dong,?Mengting Xu,?Peng Gao
Bingqing Shi,?Yuqiu Hao,?Wei Li,?Hongna Dong,?Mengting Xu,?Peng Gao
Inhibition of Histone H3 Lysine-27 Demethylase Activity Relieves Rheumatoid Arthritis Symptoms via Repression of IL6 Transcription in Macrophages
Published: 15 March 2022
DOI:
Zhan Zhao,?Yazhuo Zhang,?Danling Gao,?Yidan Zhang,?Wen-wei Han,?Ximing Xu,?Qiaoling Song,?Chenyang Zhao,?Jinbo Yang
Zhan Zhao,?Yazhuo Zhang,?Danling Gao,?Yidan Zhang,?Wen-wei Han,?Ximing Xu,?Qiaoling Song,?Chenyang Zhao,?Jinbo Yang
Peramivir, an Anti-Influenza Virus Drug, Exhibits Potential Anti-Cytokine Storm Effects
Published: 28 February 2022
DOI: 10.3389/fimmu.2022.856327
Chen-Xi Zhang,?Ye Tu,?Xiao-Chen Sun,?Da-Gui Chen,?Wan-Nian Zhang,?Chun-Lin Zhuang,?Zhi-Bin Wang,?Li Su
Chen-Xi Zhang,?Ye Tu,?Xiao-Chen Sun,?Da-Gui Chen,?Wan-Nian Zhang,?Chun-Lin Zhuang,?Zhi-Bin Wang,?Li Su
Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective.
Published: 1 January 2022
DOI: 10.3389/fimmu.2022.1072007
Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu
Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex
Published: 25 February 2021
DOI: 10.3389/fimmu.2021.618196
Feiyan Deng, Gang Xu, Zhikui Cheng, Yu Huang, Caijiao Ma, Chuanjin Luo, Chen Yu, Jun Wang, Xiupeng Xu, Shi Liu, Ying Zhu
Feiyan Deng, Gang Xu, Zhikui Cheng, Yu Huang, Caijiao Ma, Chuanjin Luo, Chen Yu, Jun Wang, Xiupeng Xu, Shi Liu, Ying Zhu
STAT6 Pathway Is Critical for the Induction and Function of Regulatory T Cells Induced by Mucosal B Cells
Published: 29 January 2021
DOI: 10.3389/fimmu.2020.615868
Kuan-Hua Chu, Szu-Yu Lin, Bor-Luen Chiang
Kuan-Hua Chu, Szu-Yu Lin, Bor-Luen Chiang
Peramivir, an Anti-Influenza Virus Drug, Exhibits Potential Anti-Cytokine Storm Effects.
Published: 14 July 2020
DOI:
Chen-xi Zhang,?Ye Tu,?Xiao-chen Sun,?Da-gui Chen,?Wannian Zhang,?Chunlin Zhuang,?Zhi-bin Wang,?L. Su
Chen-xi Zhang,?Ye Tu,?Xiao-chen Sun,?Da-gui Chen,?Wannian Zhang,?Chunlin Zhuang,?Zhi-bin Wang,?L. Su
Critical Role for the NLRP3 Inflammasome in Mediating IL-1β Production in Shigella sonnei-Infected Macrophages
Published: 3 June 2020
DOI: 10.3389/fimmu.2020.01115
Lan-Hui Li, Tzu-Ling Chen, Hsiao-Wen Chiu, Chung-Hua Hsu, Chien-Chun Wang, Tzu-Ting Tai, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V Chernikov, Wen-Chiuan Tsai, Kuo-Feng Hua
Lan-Hui Li, Tzu-Ling Chen, Hsiao-Wen Chiu, Chung-Hua Hsu, Chien-Chun Wang, Tzu-Ting Tai, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V Chernikov, Wen-Chiuan Tsai, Kuo-Feng Hua
Mechanistic Insight Into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages
Published: 31 July 2019
DOI: 10.3389/fimmu.2019.01815
Lan-hui Li,?Jia-Sing Lin,?Hsiao-Wen Chiu,?Wen-Yu Lin,?Tz-Chuen Ju,?Fang-Hsin Chen,?O. Chernikov,?May-Lan Liu,?Jen-Che Chang,?Chung-Hua Hsu,?Ann Chen,?S. Ka,?Hong-wei Gao,?Kuo-Feng Hua
Lan-hui Li,?Jia-Sing Lin,?Hsiao-Wen Chiu,?Wen-Yu Lin,?Tz-Chuen Ju,?Fang-Hsin Chen,?O. Chernikov,?May-Lan Liu,?Jen-Che Chang,?Chung-Hua Hsu,?Ann Chen,?S. Ka,?Hong-wei Gao,?Kuo-Feng Hua
Cathelicidin-WA Facilitated Intestinal Fatty Acid Absorption Through Enhancing PPAR-γ Dependent Barrier Function
Published: 17 July 2019
DOI: 10.3389/fimmu.2019.01674
X. Zong,?Xiaoxuan Cao,?Hong Wang,?Xiaohui Xiao,?Yizhen Wang,?Zeqing Lu
X. Zong,?Xiaoxuan Cao,?Hong Wang,?Xiaohui Xiao,?Yizhen Wang,?Zeqing Lu